Strain Difference of the Adrenal Cortex between A/J and SM/J Mice, Progenitors of SMXA Recombinant Inbred Group

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概要

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• The recombinant inbred (RI) mouse group is useful for genetic analysis of a phenotype which is regulated by multiple loci. The female adrenal cortex was compared histologically to detect the strain differences between A/J and SM/J for the purpose of genetic analysis of adrenocortical morphogenesis using the SMXA RI group constructed between A/J and SM/J. Clear morphological differences were found in the zona reticularis and X zone in addition to the significantly small body and adrenal weights in SM/J. The z. reticularis was markedly thicker in SM/J than in A/J and the X zone was constituted of vacuolated cells in A/J and non-vacuolated cells in SM/J. The genetic control of these morphological traits was analyzed using SMXA RI strains. The results suggest that the thickness of the z. reticularis may be controlled by single locus and that vacuolation of the X zone by 3 different loci between A/J and SM/J.

• 社団法人　日本実験動物学会の論文

著者

• MATSUZAWA Akio

  Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo

• KITOH Junzoh

  Institute for Laboratory Animal Experiment, Nagoya University School of Medicine

• TANAKA Shin

  Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)

• Kitoh J

  Nagoya Univ. Nagoya Jpn

• Kitoh Junzoh

  Institute For Laboratory Animal Research Nagoya University School Of Medicine

• Kitoh Junzoh

  名古屋大学医学部附属動物実験施設

• Kitoh Junzoh

  Emeritus Professor Of Nagoya University

• Kitoh Junzoh

  名古屋大学 医学部大学院医学系研究科

• NISHIMURA Masahiko

  Institute for Laboratory Animal Research, Nagoya University School of Medicine

• TANAKA Shin

  Laboratory Animal Research Center, Institute of Medical Science, the University of Tokyo

• Tanaka Shin

  Animal Facility For Aging Research (afar) National Center For Geriatrics And Gerontology (ncgg)

• Nishimura M

  Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch

• Nishimura Masahiko

  Institute For Experimental Animals Hamamatsu University School Of Medicine

• Kitoh Junzoh

  Institute For Experimental Animal Research Nagoya University School Of Medicine

• Tanaka Shin

  鹿児島大学 農学部獣医学科解剖学分野

• Nishimura Masahiko

  Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch

• Matsuzawa Akio

  Laboratory Animal Research Center Institute Of Medical Science The University Of Tokyo

• Tanaka Shin

  Laboratory Animal Research Center Institute Of Medical Science University Of Tokyo

• Matsuzawa Akio

  Laboratory Animal Research Center

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