Serum Adiponectin Concentration : Its Correlation with Diabetes-Related Traits and Quantitative Trait Loci Analysis in Mouse SMXA Recombinant Inbred Strains
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概要
- 論文の詳細を見る
Adiponectin is thought to be an important mediator of insulin sensitivity and atherosclerosis. Using mouse 19 SMXA recombinant inbred (RI) strains, a powerful tool for analyzing multifactorial genetic traits, we found relationships between serum adiponectin levels and diabetes-related traits, body mass index, and serum lipid levels, and also determined the loci controlling serum adiponectin levels by quantitative trait loci (QTL) analysis. RI strains exhibited widely ranging serum adiponectin concentration distribution patterns and diabetes-related traits. The serum adiponectin concentration showed the strongest negative correlation with fasting serum insulin concentration, but negative correlations were also observed with serum triglycerides, cholesterol, and liver weight. In contrast, neither the body mass index nor the blood glucose concentration correlated with serum adiponectin levels. These results suggest that hypoadiponectinemia might be used as a predictor of insulin resistance. In addition, two suggestive QTLs for serum adiponectin concentration were detected on Chromosome (Chr) 7, and an A/J allele at these loci was associated with elevated serum adiponectin concentrations. Identification of genes responsible for regulating the serum adiponectin concentration might lead to the development of novel treatments for patients with diabetes concomitant with hypoadiponectinemia.
- 社団法人 日本農芸化学会の論文
- 2006-03-23
著者
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KOBAYASHI Misato
Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya Uni
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HORIO Fumihiko
Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya Uni
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IKEGAMI Hiroshi
Department of Geriatric Medicine, Osaka University Graduate School of Medicine
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OHNO Tamio
Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate S
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Ohno T
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Ohno Tamio
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Horio F
Nagoya Univ. Nagoya Jpn
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Horio Fumihiko
Department Of Agricultural Chemistry Nagoya University
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Horio Fumihiko
Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive
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KAWADA Teruo
Laboratory for Molecular Function of Food, Division of Food Science and Biotechnology, Graduate Scho
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Nishimura M
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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NISHIMURA Masahiko
Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate S
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Kawai Takahiro
Laboratory Of Molecular Function Of Food Division Of Food Science And Biotechnology Graduate School
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Ikegami Hiroshi
Department Of Endocrinology Metabolism And Diabetes Kinki University School Of Medicine
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Nishimura Masahiko
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Kobayashi Misato
Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive
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Kawada Teruo
Lab. Of Molecular Function Of Food Div. Of Food Sci. And Biotechnology Graduate School Of Agricultur
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Kawada Teruo
Laboratory For Molecular Function Of Food Division Of Food Science And Biotechnology Graduate School
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Ikegami Hiroshi
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Ikegami Hiroshi
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Kobayashi Misato
Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya University
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