β-Conglycinin Lowers Very-Low-Density Lipoprotein-Triglyceride Levels by Increasing Adiponectin and Insulin Sensitivity in Rats
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概要
- 論文の詳細を見る
The relationship between insulin sensitivity and the plasma triglyceride-lowering effect induced by β-conglycinin was investigated. Male Wistar rats (19 weeks old) were fed diets containing casein, soy protein isolate, or β-conglycinin for 4 weeks. In oral glucose administration, the β-conglycinin-fed rats showed a significant decrease in the area under the glucose curve (0–60 min) as compared with the casein-fed rats. The hypoglycemic effect was significantly higher in the β-conglycinin-fed rats than in the casein-fed rats at 30 min after intraperitoneal insulin injection. The liver sterol regulatory element-binding-protein-1 mRNA expression level was significantly lower and the plasma adiponectin concentration was significantly higher in the β-conglycinin-fed rats than in the casein-fed rats. The hypotriglyceridemic effect of β-conglycinin depended on a significant decrease in the concentration of very-low-density-lipoprotein triglycerides. These results indicate that β-conglycinin increases adiponectin levels and improves glucose tolerance. The ability of β-conglycinin to lower plasma lipid levels might be due to increased insulin sensitivity of the liver.
- 社団法人 日本農芸化学会の論文
- 2010-06-23
著者
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Horio Fumihiko
Department Of Agricultural Chemistry Nagoya University
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Kito M
Food Science Research Institute Fuji Oil Co. Ltd.
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Kohno Mitsutaka
Food Science Research Institute Tsukuba Research & Development Center Fuji Oil Co. Ltd.
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TACHIBANA Nobuhiko
Food Science Research Institute, Fuji Oil Co., Ltd.
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Hirotsuka Motohiko
Food Science Institute Fuji Oil Co. Ltd.
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Horio Fumihiko
Department Of Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya University
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IWAOKA Yasue
Food Science Institute, Fuji Oil Co., Ltd.
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Iwaoka Yasue
Food Science Institute Fuji Oil Co. Ltd.
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Tachibana Nobuhiko
Food Science Institute Fuji Oil Co. Ltd.
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