Ascorbic Acid Deficiency Stimulates Hepatic Expression of Inflammatory Chemokine, Cytokine-Induced Neutrophil Chemoattractant-1, in Scurvy-Prone ODS Rats
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概要
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ODS rat has a hereditary defect in ascorbic acid biosynthesis and is a useful animal model for elucidating the physiological role of ascorbic acid. We previously demonstrated by using ODS rats that ascorbic acid deficiency changes the hepatic gene expression of acute phase proteins, as seen in acute inflammation. In this study, we investigated the effects of ascorbic acid deficiency on the production of inflammatory chemokine, cytokineinduced neutrophil chemoattractant-1 (CINC-1), in ODS rats. Male ODS rats (6 wk of age) were fed a basal diet containing ascorbic acid (300mg/kg diet) or a diet without ascorbic acid for 14 d. Obvious symptoms of scurvy were not observed in the ascorbic acid-deficient rats. Ascorbic acid deficiency significantly elevated the serum concentration of CINC-1 on d 14. The liver and spleen CINC-1 concentrations in the ascorbic acid-deficient rats were significantly elevated to 600% and 180% of the respective values in the control rats. However, the lung concentration of CINC-1 was not affected by ascorbic acid deficiency. Ascorbic acid deficiency significantly elevated the hepatic mRNA level of CINC-1 (to 480% of the value in the control rats), but not the lung mRNA level. These results demonstrate that ascorbic acid deficiency elevates the serum, liver and spleen concentrations of CINC-1 as seen in acute inflammation, and suggest that ascorbic acid deficiency stimulate the hepatic CINC-1 gene expression.
- 日本ビタミン学会の論文
著者
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KOBAYASHI Misato
Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya Uni
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HORIO Fumihiko
Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya Uni
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Horio Fumihiko
Dep. Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Univ. Jpn
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Horio Fumihiko
Department Of Agricultural Chemistry Nagoya University
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Horio Fumihiko
Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive
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Tsuda Takanori
Research Center For Biomarkers Of Preventive Medicine Doshisha University
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Kobayashi Misato
Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive
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KIYAMA Keiichiro
Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya Univ
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KAWAI Kaori
Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya Univ
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Kiyama Keiichiro
Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya Univer
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Kawai Kaori
Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya Univer
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Kawai Kaori
Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya Univer
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Kobayashi Misato
Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya University
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