Ascorbic acid deficiency elevates serum level of LDL-cholesterol in a rat mutant unable to synthesize ascorbic acid.
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概要
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The effect of ascorbic acid deficiency on serum levels of high density lipoprotein- (HDL-), low density lipoprotein- (LDL-), very low density lipoprotein- (VLDL-) and chylomicron-cholesterol was examined in ODS-od/od rat (ODS rat), that is a rat mutant unable to synthesize ascorbic acid. Male ODS rats were fed an ascrobic acid-free diet for 20 days. In another two groups, the diet supplemented with 300mg ascorbic acid/kg diet was fed either ad libitum (ad libitum control) or in pair-feeding (pair-fed control). Pair-fed rats received the same amount of diet as rats fed the ascorbic acid-free diet. Serum level of total cholesterol in the ad libitum control rats, ascorbic acid-deficient rats, and the pair-fed control rats were 100.1±8.4mg/dl, 92.8±6.2mg/dl and 72.2±4.8mg/dl, respectively. The level of LDL-cholesterol in ascorbic acid-deficient rats was significantly higher than that in the ad libitum control or that in the pair-fed control. The level of HDL-cholesterol in ascorbic acid-deficient rats was lower than that in the ad libitum control, but was not changed as compared with that in the pair-fed control. Ascorbic acid deficiency did not affect serum level of VLDL-cholesterol or chylomicron-cholesterol as compared with those in the controls. These results demonstrate that ascorbic acid deficiency causes the elevation of serum level of LDL-cholesterol both in ad libitum feeding condition and pair feeding condition.
- 財団法人 学会誌刊行センターの論文
著者
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Makino Susumu
Aburahi Laboratories Shionogi & Co. Ltd.
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Horio Fumihiko
Department Of Agricultural Chemistry Nagoya University
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Takahashi Naoko
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Yoshida Akira
Department Of Agricultural Chemistry Nagoya University
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HAYASHI Yoshiyuki
Aburahi Laboratories, Shionogi & Co., Ltd.,
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HORIO Fumihiko
Department of Agriculutral Chemistry, Nagoya University
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HAYASHI Yoshiyuki
Aburahi Laboratories, Shionogi Research Laboratories, Shiologi & Co., Ltd.
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MAKINO Susumu
Aburahi Laboratories, Shionogi Research Laboratories, Shiologi & Co., Ltd.
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TAKAHASHI Naoko
Department of Agriculutral Chemistry, Nagoya University
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