Role of N-Acetylglutamate Turnover in Urea Synthesis by Rats Treated with the Thyroid Hormone
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概要
- 論文の詳細を見る
We determined whether the synthesis and degradation of N-acetylglutamate would regulate urea synthesis when the thyroid status was manipulated.Experiments were done on three groups of rats, each being given 6-propyl-2-thiouracil(PTU, a thyroid inhibitor)without a triiodothyronine(T_3)treatment, treated with PTU+T_3, or receiving neither PTU nor T_3(control).The plasma concentration and urinary excretion of urea, the liver concentration of N-acetylglutamate, and the liver N-acetylglutamate synthesis in rats given PTU alone were each significantly higher than in the control rats.Compared with the control rats, the liver N-acetylglutamate degradation was significantly lower in those rats given PTU without the T_3 treatment.Treatment of the PTU-treated rats with T_3 reversed the effects of PTU to the values of the control rats. N-Acetylglutamate synthesis in the liver was closely correlated with the excretion of urea, and inverse correlation between the liver N-acetyl-glutamate degradation and urea excretion was found. These results suggest that the greater synthesis and lower degradation of N-acetylglutamate in the hypothyroid(PTU alone)rats would be likely to increase the hepatic concentration of this compound and stimulate urea synthesis.
- 社団法人日本農芸化学会の論文
- 1998-03-23
著者
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Yabe Aya
Department Of Molecular Biology Institute Of Gerontology Nippon Medical School
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HAYASE Kazutoshi
Department of Home Economics, Aichi University of Education
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YOSHIDA AKIRA
Department of Radiological Sciences, Hiroshima Prefectural College of Health Science
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Hayase Kazutoshi
Department Of Home Economics Aichi University Of Education
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Yoshida Akira
First Department Of Internal Medicine University Of Fukui
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Koie Miho
Department Of Home Economics Aichi University Of Education
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Naganuma Yaeko
Deparmtent Of Home Economics Aichi University Of Education
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Hayase K
Department Of Home Economics Aichi University Of Education
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Yoshida Akira
Department Of Cardiology Kyoto National Hospital
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Yoshida Akira
Department Of Agricultural Chemistry Nagoya University
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