Effects of Ethanol and Polychlorinated Biphenyls in Combination on Ascorbic Acid Metabolism, Liver Drug-metabolizing Enzymes, and Lipid Metabolism in Rats
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概要
- 論文の詳細を見る
We investigated the combined effects of ethanol and polychlorinated hiphenyls (PCB) on ascorbic acid metabolism, liver drug-metabolizing enzymes, and lipid metabolism in rats fed on a diet containing by 36% by energy of ethanol and 0.005% of PCB, either singly or in combination, for 49 days. Ethanol and PCB given together synergistically affected the amount of ascorbic acid excreted in the urine and the serum concentration of ascorbic acid. This synergistic effect was also observed in the activity of aniline hydroxylase in the liver. Ethanol and PCB given together seem to have had different effects on lipid metabolism. These results suggest that the effect of ethanol on the metabolism of ascorbic acid and of drugs may be enhanced by combined administration with PCB, and that the ascrobic acid deficiency and/or modification of the drug metabolism may become more serious.
- 社団法人日本農芸化学会の論文
- 1992-12-23
著者
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Yabe Aya
Department Of Molecular Biology Institute Of Gerontology Nippon Medical School
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Watanabe Y
Faculty Of Education Oita University
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YOSHIDA Akira
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, School of Agriculture,
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Mochizuki Satoshi
Faculty Of Education And Welfare Science Oita University
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Yoshida Akira
First Department Of Internal Medicine University Of Fukui
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Kato K
United Graduate School Of Agricultural Science Gifu University
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Kato Keiko
Faculty of Education, Oita University
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Watanabe Yuko
Faculty of Education, Oita University
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Watanabe Yuko
Faculty Of Agriculture Yamaguchi University
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Yoshida Akira
Laboratory Of Nutritional Biochemistry Department Of Agricultural Chemistry Nagoya University
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