Cholesterol-rich Very Low Density Lipoproteins and Fatty Liver in Rats Fed Polychlorinated Biphenyls
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概要
- 論文の詳細を見る
Feeding xenobiotics such as polychlorinated biphenyls (PCB) causes hypercholesterolemia and fatty liver in rats. The hypercholesterolemia was characterized by high levels of high density lipoproteins (HDL)and apolipoprotein A-I (apo A-I), and by very low density lipoproteins (VLDL) rich in cholesterol and apo E (designated "PCB-VLDL"). The mechanisms for the generation of "PCB-VLDL" and fatty liver, and for hyper-α-lipoproteinemia in rats fed PCB were investigated. The secretion rate of VLDL-lipids was increased by PCB on day 3, while the secretion rate of only VLDL-cholesterol and phospholipid were increased by PCB on days 8 and 57. Although all liver lipids were accumulated by PCB, the accumulation of esterified cholesterol was the most drastic. These results suggested that PCB stimulated the secretion of VLDL at the early period of PCB feeding (on day 3), and that cholesterol-rich VLDL, "PCB-VLDL", was not generated in the circulation, but was originally secreted from the liver. In spite of the stimulation of VLDL secretion, liver lipids accumulated within 8 days on the PCB diet. On days 3 and 8, serum levels of free fatty acids were not changed by PCB feeding. These data and our previous findings that PCB induced hepatic lipogenic enzymes lead us to speculate that fatty liver induced by PCB may be attributed to a stimulation of de novo synthesis of liver lipids. Even when hepatic secretion of VLDL was blocked by orotic acid, HDL-cholesterol was increased by PCB feeding, suggesting that the increase in serum level of HDL by PCB was not due to stimulation of cholesterol transport into HDL from VLDL.
- 社団法人日本農芸化学会の論文
- 1994-12-23
著者
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Yabe Aya
Department Of Molecular Biology Institute Of Gerontology Nippon Medical School
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Matsushita Natsuki
Laboratory Of Nutritional Biochemistry School Of Agricultural Sciences Nagoya University
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YOSHIDA Akira
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, School of Agriculture,
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Yoshida Akira
First Department Of Internal Medicine University Of Fukui
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Oda H
Nagoya Univ. Aichi Jpn
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Oda H
Department Of Applied Biological Sciences Nagoya University
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Oda Hiroaki
Laboratory Of Nutritional Biochemistry Department Of Agricultural Chemistry Nagoya University
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Oda Hiroaki
Department Of Applied Biological Sciences Nagoya University
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Hirabayashi Akiji
Laboratory of Nutritional Biochemistry, Department of Applied Biological Sciences, Nagoya University
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Hirabayashi Akiji
Laboratory Of Nutritional Biochemistry Department Of Applied Biological Sciences Nagoya University
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Yoshida Akira
Laboratory Of Nutritional Biochemistry Department Of Agricultural Chemistry Nagoya University
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