Contribution of Gastric Emptying to the Blood Ethanol-Lowering Effect of Acetic Acid(Food & Nutrition)

概要

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Blood ethanol concentrations are decreased by the oral administration of ethanol with acetic acid. The slowing of gastric emptying is supposed to be one of the mechanisms for the blood ethanol-lowering effect. In the present study, to further clarify the contribution of gastric emptying to this effect, we investigated the blood ethanol concentration, and the amounts of ethanol remaining in the stomach and in the small intestine, after orally administering ethanol with acetic acid or various salts of acetic acid. This was done under two conditions in which the osmolarity or concentration of the acetate ion in each administered solution was equalized. The blood ethanol-lowering effect of acetic acid was weakened by replacing acetic acid with sodium, potassium, or calcium acetate. There was a good negative correlation between the blood ethanol concentration and the amount of ethanol remaining in the stomach one hour after administering the sample solutions. The amount of ethanol remaining in the small intestine was not increased in the acetic acid group. From these results, the slowing of gastric emptying is considered to be the major mechanism for the blood ethanol-lowering effect of acetic acid, and is presumed to be controlled by cations of the solution, and not by the acetate ion.
社団法人日本農芸化学会の論文
1990-10-23