A Freshwater Clam (Corbicula fluminea) Extract Improves Cholesterol Metabolism in Rats Fed on a High-Cholesterol Diet
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概要
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The effect of a freshwater clam (Corbicula fluminea) extract (FCE) on cholesterol metabolism in rats fed on a high-cholesterol diet was investigated. When rats were fed various amounts of FCE in addition to the high-cholesterol diet for 2 wk, the serum and hepatic cholesterol levels were gradually reduced in a dose-dependent manner, as compared with the control group. The excretion of neutral sterols and bile acids into the feces was increased by feeding FCE. Several phytosterols were detected in the feces of rats fed on the FCE-containing diet. In addition, substantial amounts of phytosterols were found in FCE. Cholesterol 7α-hydroxylase (CYP7A1) mRNA in the liver of the rats fed on the FCE-containing diets was higher than that of rats fed on the high-cholesterol diets without FCE. These results may suggest that enhanced cholesterol degradation and the excretion of neutral sterols and bile acids contributed to the hypocholesterolemic effect of FCE observed in the hypercholesterolemic rats fed on the high-cholesterol diet.
- 社団法人 日本農芸化学会の論文
著者
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Mochizuki Satoshi
Faculty Of Education And Welfare Science Oita University
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CHIJIMATSU Takeshi
Sasaki Food Co., Ltd.
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TATSUGUCHI Iwao
Department of Applied Molecular Biosciences, Nagoya University
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ABE Kazuaki
Shizenshokken Co., Ltd.
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ODA Hiroaki
Department of Applied Molecular Biosciences, Nagoya University
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