High Responsiveness to Thyroid Hormone of Adult Rat Primary Hepatocytes Cultured on EHS-Gel

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概要

• 論文の詳細を見る

• The induction of malic enzyme gene expression by triiodothyronine and insulin was severely blunted in rat monolayer hepatocytes cultured on type I collagen compared with that in spherical hepatocytes cultured on a reconstituted basement membrane gel (EHS-gel). Although the mRNA level of thyroid hormone receptor β (TRβ) gradually decreased in the monolayer hepatocytes during culture, the mRNA level in the hepatocytes on EHS-gel was maintained at around the in vivo level. Our results suggest that the maintenance of TRβ mRNA on EHS-gel is responsible for the high responsiveness to thyroid hormone in a hepatocyte culture.

• 社団法人日本農芸化学会の論文
• 1997-09-23

著者

• Iwasaki Yukiko

  Laboratory Of Nutritional Biochemistry Department Of Applied Biological Sciences Nagoya University

• Oda Hiroaki

  Laboratory Of Nutritional Biochemistry Department Of Agricultural Chemistry Nagoya University

• Nozawa Katsura

  Laboratory Of Nutritional Biochemistry Department Of Applied Biological Sciences Nagoya University

• Nozawa Katsura

  Laboratory Of Cancer Cell Biology Research Institute For Disease Mechanism And Control Nagoya Univer

• Shimizu Ai

  Laboratory Of Nutritional Biochemistry Department Of Applied Biological Sciences Nagoya University

• MIYACHI Fuyuko

  Laboratory of Nutritional Biochemistry, Department of Applied Biological Sciences, Nagoya University

• KAKINUMA Atsushi

  Laboratory of Nutritional Biochemistry, Department of Applied Biological Sciences, Nagoya University

• Miyachi Fuyuko

  Laboratory Of Nutritional Biochemistry Department Of Applied Biological Sciences Nagoya University

• Kakinuma Atsushi

  Laboratory Of Nutritional Biochemistry Department Of Applied Biological Sciences Nagoya University

• Oda Hiroaki

  Laboratory of Nutritional Biochemistry, Department of Applied Biological Sciences, Nagoya University

関連論文

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• Small Scale Rat Hepatocyte Primary Culture with Applications for Screening Hepatoprotective Substances(Food & Nutrition Science)
• High Responsiveness to Thyroid Hormone of Adult Rat Primary Hepatocytes Cultured on EHS-Gel
• Cholesterol-rich Very Low Density Lipoproteins and Fatty Liver in Rats Fed Polychlorinated Biphenyls
• Induction of Cytochrome P-450s and Expression of Liver-specific Genes in Rat Primary Hepatocytes Cultured on Different Extracellular Matrices

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