Role of the Nh (Non-hair) Mutation in the Development of Dermatitis and Hyperproduction of IgE in DS-Nh Mice

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概要

• 論文の詳細を見る

• The DS-Nh (DS Non-hair) mouse is a spontaneous hairless mutant of the DS mouse. The inheritance mode of the Nh mutation is autosomal dominant, and the Nh locus is mapped to Chromosome 11. The roles of the Nh mutation in spontaneous dermatitis and IgE hyperproduction were studied using an Nh congenic strain with a genetic background from the BALB/c mouse. In contrast to DS-Nh (Nh/+) mice, BALB/c-Nh (Nh/+) mice under conventional conditions showed a marked increase in serum IgE, without the development of dermatitis. These results suggest that IgE hyperproduction is regulated by the Nh mutation, while other genetic factor(s) are also involved in the development of dermatitis.

• 社団法人　日本実験動物学会の論文
• 2003-10-01

著者

• 渡辺 明

  東北大多元研

• Makino Susumu

  Aburahi Laboratories Shionogi & Co. Ltd.

• Makino S

  Shionogi And Co. Ltd. Shiga Jpn

• Makino S

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• Makino Susumu

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• Nakao Hiroyuki

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• HIRASAWA Tsutomu

  Shionogi Institute for Medical Science

• NAKAMURA Kazuichi

  Developmental Research Laboratories, Shionogi & Co., Ltd.

• WATANABE Akira

  Development Research Laboratories, Shionogi & Co., Ltd.

• TAKEUCHI Mitsuo

  Development Research Laboratories, Shionogi & Co., Ltd.

• NAGATA Masafumi

  Development Research Laboratories, Shionogi & Co., Ltd.

• YAMASHITA Hirofumi

  Shionogi Research Laboratories, Shionogi & Co., Ltd.

• HARADA Minoru

  Development Research Laboratories, Shionogi & Co., Ltd.

• Yamashita Hirofumi

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• Hirasawa T

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• Yamashita H

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• Nakazawa Mikio

  Dep. Of Medical Technol. School Of Health Sci. Fac. Of Medicine Niigata Univ.

• Takeuchi Mitsuo

  Development Research Laboratories Shionogi & Co. Ltd.

• Horikawa Tatsuya

  Department Of Dermatology Kobe University School Of Medicine

• Nakamura Kazuichi

  Development Research Laboratories Shionogi & Co. Ltd.

• Harada Minoru

  Development Research Laboratories Shionogi & Co. Ltd.

• Watanabe Akira

  Development Research Laboratories Shionogi & Co. Ltd.

• NAKAO Hiroyuki

  Shionogi Research Laboratories

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