Role of the Nh (Non-hair) Mutation in the Development of Dermatitis and Hyperproduction of IgE in DS-Nh Mice
スポンサーリンク
概要
- 論文の詳細を見る
The DS-Nh (DS Non-hair) mouse is a spontaneous hairless mutant of the DS mouse. The inheritance mode of the Nh mutation is autosomal dominant, and the Nh locus is mapped to Chromosome 11. The roles of the Nh mutation in spontaneous dermatitis and IgE hyperproduction were studied using an Nh congenic strain with a genetic background from the BALB/c mouse. In contrast to DS-Nh (Nh/+) mice, BALB/c-Nh (Nh/+) mice under conventional conditions showed a marked increase in serum IgE, without the development of dermatitis. These results suggest that IgE hyperproduction is regulated by the Nh mutation, while other genetic factor(s) are also involved in the development of dermatitis.
- 社団法人 日本実験動物学会の論文
- 2003-10-01
著者
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渡辺 明
東北大多元研
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Makino Susumu
Aburahi Laboratories Shionogi & Co. Ltd.
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Makino S
Shionogi And Co. Ltd. Shiga Jpn
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Makino S
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Makino Susumu
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Nakao Hiroyuki
Shionogi Research Laboratories Shionogi & Co. Ltd.
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HIRASAWA Tsutomu
Shionogi Institute for Medical Science
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NAKAMURA Kazuichi
Developmental Research Laboratories, Shionogi & Co., Ltd.
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WATANABE Akira
Development Research Laboratories, Shionogi & Co., Ltd.
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TAKEUCHI Mitsuo
Development Research Laboratories, Shionogi & Co., Ltd.
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NAGATA Masafumi
Development Research Laboratories, Shionogi & Co., Ltd.
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YAMASHITA Hirofumi
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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HARADA Minoru
Development Research Laboratories, Shionogi & Co., Ltd.
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Yamashita Hirofumi
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Hirasawa T
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Yamashita H
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Nakazawa Mikio
Dep. Of Medical Technol. School Of Health Sci. Fac. Of Medicine Niigata Univ.
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Takeuchi Mitsuo
Development Research Laboratories Shionogi & Co. Ltd.
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Horikawa Tatsuya
Department Of Dermatology Kobe University School Of Medicine
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Nakamura Kazuichi
Development Research Laboratories Shionogi & Co. Ltd.
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Harada Minoru
Development Research Laboratories Shionogi & Co. Ltd.
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Watanabe Akira
Development Research Laboratories Shionogi & Co. Ltd.
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NAKAO Hiroyuki
Shionogi Research Laboratories
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