WBN/Kob-Ht Rats Spontaneously Develop Dermatitis under Conventional Conditions : Another Possible Model for Atopic Dermatitis
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概要
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WBN/Kob-Ht rats (Ht-rats) raised under conventional conditions spontaneously developed dermatitis. In this study, we carried out histopathological analysis to elucidate the pathological features of the dermatitis in Ht-rats. We then tried to detect Staphylococcus species recovered from the skin lesions of Ht-rats. We also measured the serum levels of total IgE, IL-4 and IFN-γ in these rats. The histopathological data indicated that inflammatory cells had infiltrated the skin lesions. Staphylococcus aureus was recovered from the skin lesions, and the serum levels of total IgE and IL-4 were elevated in Ht-rats with dermatitis. These results suggest that dermatitis in Ht-rats is similar to that in the DS-Nh mice, which has recently been proposed as an animal model for human atopic dermatitis.
- 2005-10-01
著者
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HIRASAWA Tsutomu
Shionogi Institute for Medical Science
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Hirasawa T
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Hirasawa Tsutomu
Discovery Research Laboratories Department Of Animal Resource Shionogi & Co. Ltd.
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Sakata Tsuneaki
Shionogi Discovery Research Laboratories Shionogi Co. Ltd.
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Horikawa Tatsuya
Department Of Dermatology Kobe University School Of Medicine
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Horikawa Tatsuya
Division Of Dermatology Department Of Clinical Molecular Medicine Kobe University Graduate School Of
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Hikita Ichiro
Shionogi Discovery Research Laboratories Shionogi Co. Ltd.
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Asakawa Makoto
Shionogi Discovery Research Laboratories Shionogi Co. Ltd.
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YOSHIOKA Takeshi
Shionogi Discovery Research Laboratories, Shionogi Co., Ltd.
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MATSUTANI Takaji
Division of Immunology and Embryology, Department of Cell Biology, Tohoku University School of Medic
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ARIMURA Akinori
Shionogi Discovery Research Laboratories, Shionogi Co., Ltd.
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Arimura Akinori
Shionogi Discovery Research Laboratories Shionogi Co. Ltd.
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Yoshioka Takeshi
Shionogi Discovery Research Laboratories Shionogi Co. Ltd.
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Matsutani Takaji
Division Of Immunology And Embryology Department Of Cell Biology Tohoku University School Of Medicin
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