5-Hydroxytryptamine Receptors, Especially the 5-HT_4 Receptor, in Guinea Pig Urinary Bladder
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概要
- 論文の詳細を見る
The function of 5-hydroxytryptamine (5-HT) receptors, especially the 5-HT4 receptor, in the urinary bladder were examined in preparations isolated from the guinea pig by in vitro receptor autoradiography and determinations of mechanical activity and acetylcholine (ACh) release. Specific [125I]SB207710 binding sites were detected evenly throughout the urinary bladder. 5-HT (3 × 10−8 – 10−4 M) caused contractions of strips of the urinary bladder, in a concentration dependent manner. Ketanserin antagonized the 5-HT-induced contractions, while granisetron and SB204070 antagonized the contractions induced by high concentrations of 5-HT. Atropine inhibited the contractions induced by high concentrations of 5-HT. Ketanserin prevented the 5-HT-induced contractions in the presence of atropine, but granisetron and SB204070 did not affect the contractions under such a condition. 5-HT enhanced the electrically-stimulated (5 Hz, 0.5 ms) outflow of [3H]acetylcholine from strips preloaded with [3H]choline, and the enhancement was antagonized by granisetron and SB204070. Thus, the contractile response to 5-HT was mediated by activations of 5-HT2, 5-HT3 and 5-HT4 receptors. The 5-HT2 receptor may be a property of high affinity to 5-HT and located on the smooth muscle cells. The 5-HT4 as well as 5-HT3 receptor may be a property of low affinity to 5-HT and located on the cholinergic neurons.
- 社団法人 日本薬理学会の論文
- 2002-08-01
著者
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TANAKA NOBUYUKI
Department of Botany, Kochi Prefectural Makino Botanical Garden
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YOSHIDA AKIRA
Department of Radiological Sciences, Hiroshima Prefectural College of Health Science
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Taniyama Kohtaro
Department Of Pharmacology Nagasaki University Graduate School Of Biomedical Sciences
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Yamashita Yasuko
Department Of Pharmacology Nagasaki University School Of Medicine
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Kaibara Muneshige
Department Of Pharmacology Nagasaki University Graduate School Of Biomedical Sciences
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Yoshida Akira
Department Of Breast And Endocrine Surgery Kanagawa Cancer Center
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Yoshida Akira
Department Of Rehabilitation And Physical Medicine Faculty Of Medicine Kagoshima University
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Yoshida Akira
Department Of Agricultural Chemistry Nagoya University
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Tanaka Nobuyuki
Department Of Botany Kochi Prefectural Makino Botanical Garden
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S.-Yamashita Yasuko
Department of Pharmacology, Nagasaki University School of Medicine
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Taniyama Kohtaro
Department of Pharmacology 2, Nagasaki University School of Medicine
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