Confirmation of Diabetes-Related Quantitative Trait Loci Derived from SM/J and A/J Mice by Using Congenic Strains Fed a High-Carbohydrate or High-Fat Diet

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概要

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• The interaction between causative genes and diet is known to influence the onset of obesity and diabetes in humans, although it has remained difficult to identify diabetogenic gene(s) because humans are genetically and environmentally heterogeneous. Mouse SMXA recombinant inbred (RI) strains are established from parental inbred strains (SM/J and A/J) and have been shown to be beneficial tools for analyzing polygenic traits. We previously mapped a significant quantitative trait locus (QTL, T2dm1sa) on Chromosome (Chr.) 10 and suggestive QTLs on Chr. 2, 6, and 18 for diabetes-related traits by using SMXA RI strains fed a high-carbohydrate diet. As a first step in identifying the responsible gene among QTLs for glucose tolerance mapped on Chr. 10 and 18, we established new strains of A.SM-T2dm1sa and SM.A-D18Mit19-D18Mit7 congenic mice. Each congenic strain bears the diabetogenic allele of an introgressed chromosomal region on a genetic background strain carrying the non-diabetogenic allele. The diabetogenic effect of T2dm1sa mapped on Chr. 10 was not supported by studies of A.SM-T2dm1sa congenic mice when the mice were fed a high-carbohydrate or high-fat diet. SM.A-D18Mit19-D18Mit7 congenic mice showed impaired glucose tolerance not only when they were fed a high-carbohydrate diet, but also when they were fed a high-fat diet. Thus, it appears that gene(s) affecting diabetes-related traits under either dietary condition may be present on Chr. 18.

• 財団法人 学会誌刊行センターの論文
• 2009-06-01

著者

• KOBAYASHI Misato

  Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya Uni

• HORIO Fumihiko

  Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya Uni

• MURAI Atsushi

  Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya Uni

• OHNO Tamio

  Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate S

• Ohno T

  Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch

• Ohno Tamio

  Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch

• Hoshino Hiromi

  Department Of Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine

• Hoshino Hiromi

  Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive

• Horio F

  Nagoya Univ. Nagoya Jpn

• Horio Fumihiko

  Department Of Agricultural Chemistry Nagoya University

• Horio Fumihiko

  Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive

• Ozawa Takashi

  Department of Applied Biochemistry, College of Agriculture, Osaka Prefecture University

• Nishimura M

  Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch

• HADA Natsuko

  Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya Univ

• UMESHITA Kazuhiko

  Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya Univ

• NISHIMURA Masahiko

  Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate S

• Hada Natsuko

  Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya Univer

• Umeshita Kazuhiko

  Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya Univer

• Nishimura Masahiko

  Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch

• Murai Atsushi

  Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive

• Kobayashi Misato

  Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive

• Ozawa Takashi

  Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya Univer

• Ozawa Takashi

  Departmant Of Chemistry Faculty Of Engineering Shibaura Institute Of Technology

• Murai Atsushi

  Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive

• Murai Atsushi

  Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya University

• Kobayashi Misato

  Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya University

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