Bone Mineral Analysis through Dual Energy X-Ray Absorptiometry in Laboratory Animals
スポンサーリンク
概要
- 論文の詳細を見る
To determine how to eliminate species difference in animal bone experiment, bone mineral content (BMC) was measured using dual energy X-ray absorptiometry (DXA) on the femurs of laboratory mice (Mus musculus) and rats (Rattus norvegicus), and common marmosets (Callithrix jacchus). Measures were taken on femurs in situ, detached from the body, skinned and defleshed, or dried completely. When the BMC of the bone measured in the intact limb attached to the trunk was set at 100%, the actual BMC of the dry bone was 58.7 ± 11.5% in mice and 103.2 ± 3.2% in rats. Similarly, the bone area (Area) and bone mineral density (BMD) of the dried femur was significantly lower in the mouse femurs than intact limb. Thus, soft limb tissue such as skin and muscle modified the BMC, Area, and BMD only in mouse but not in those from rats or marmosets. The bone mineral ratio (BMR; BMC divided by dry bone weight) was nearest to the human bone value in the rat femurs, whereas the mouse femur BMR was the most different. The BMR was proved to be a practical index in evaluating bone characteristics in laboratory animals, but the mouse femur might not be suitable as an animal model for research into the aging of human bone.
著者
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TSUJIO Masashi
Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)
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MIZOROGI Toshihiro
Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)
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NISHIJIMA Kazutoshi
Division of Biological Resources and Development, Analysis Research Center for Experimental Sciences
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KUWAHARA Sachi
Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)
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OHNO Tamio
Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate S
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TANAKA Shin
Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)
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Ohno Tamio
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Tanaka Shin
Animal Facility For Aging Research (afar) National Center For Geriatrics And Gerontology (ncgg)
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Tsujio Masashi
Animal Facility For Aging Research (afar) National Center For Geriatrics And Gerontology (ncgg)
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Kuwahara Sachi
Animal Facility For Aging Research (afar) National Center For Geriatrics And Gerontology (ncgg):depa
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Mizorogi Toshihiro
Animal Facility For Aging Research (afar) National Center For Geriatrics And Gerontology (ncgg)
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Nishijima Kazutoshi
Division Of Biological Resources And Development Analysis Research Center For Experimental Sciences
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KITAMURA Itsuko
General Studies Division, Aichi Gakuin University
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MAEDA Yasuhiro
ALOKA, Co., Ltd.
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NIIDA Shunpei
Laboratory of Genomics and Proteomics, National Center for Geriatrics and Gerontology (NCGG)
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NAGAYA Masahiro
Geriatric Health Services Facility, Luminous Obu
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SAITO Ryoichi
CLEA Japan, Inc.
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Tanaka Shin
Animal Facilities For Aging Research National Institute For Longevity Sciences (nils) National Cente
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Nishijima Kazutoshi
Division of Biological Resources and Development, Analysis Research Center for Experimental Sciences, Saga University
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Ohno Tamio
Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate School of Medicine, Nagoya University
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