Changes of Estrous Cycles with Aging in Female F344/N Rats
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概要
- 論文の詳細を見る
Changes of estrous cycles with aging of F344/N rats between 1 and 30 months of age (M) were monitored by vaginal smear cytology. The vaginal opening and first cornified cell phase were identified at 1.3 ± 0.1 M and 1.5 ± 0.2 M, respectively. Thereafter, estrous cycles showed about 5-day intervals, and ceased at 16.4 ± 1.2 M. Thereafter irregular appearance of single cornified cell phases without the preceding of nucleated cell phases interspersed with a predominant leukocyte phase was seen in vaginal smears until 26.9 ± 0.5 M. Growing and mature follicles as well as corpora lutea persisted until at least 30 M, and characterized the post reproductive aging of F344/N females. The F344/N rats seem to resemble humans in that the cessation of estrous cycles occurs at approximately half their entire lifespan. However, other aging characteristics are unknown in postmenopausal women. Therefore, we must be careful when extrapolating the aging changes of reproduction in F344/N rats to human beings.
著者
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Ohno Tamio
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Kuwahara Sachi
Animal Facility For Aging Research (afar) National Center For Geriatrics And Gerontology (ncgg):depa
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NISHIJIMA Kazutoshi
Animal Facility for Aging Research (AFAR), National Center for Geriatrics and Gerontology (NCGG)
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Aoyama Hiroaki
Laboratories Of Reproductive Toxicology Institute Of Environmental Toxicology
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Tanaka Shin
Animal Facilities For Aging Research National Institute For Longevity Sciences (nils) National Cente
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Sone Keiko
Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS), National Center for Geriatrics and Gerontology (NCGG)
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Yamamoto-Sawamura Takako
Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS), National Center for Geriatrics and Gerontology (NCGG)
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NISHIJIMA Kazutoshi
Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS), National Center for Geriatrics and Gerontology (NCGG)
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