Delayed Development of Reflexes and Hyperactive Locomotion in the Spontaneous Mutant "Waltzing" of the Musk Shrew, Suncus murinus

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概要

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• The autosomal recessive mutation waltzing (wz), displaying abnormal circling and head-shaking behavior, has previously been reported in the musk shrew (Suncus murinus). Postnatal development of reflexes and locomotor patterns in an open arena were examined in wz/wz mutant shrews. The wz/wz shrews showed extreme developmental delays in surface-righting reflex and negative geotaxis until 10-16 days after birth, but both reflexes eventually recovered to the levels of +/wz normal. Nevertheless, the wz/wz adults exhibited bi-directional circling behavior 59 times, head-tossing behavior 22 times and horizontal head-shaking behavior 6 times more frequent than in the +/wz controls. Although the wz/wz adult shrews were extremely hyperactive with daily spontaneous locomotor activity exceeding 4-7 times control shrew activity, they appeared to have a normal circadian rhythm. This shrew mutant may therefore be useful as a model for hyperactivity syndromes in humans.

• 社団法人　日本実験動物学会の論文

著者

• NAMIKAWA Takao

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• ISHIKAWA Akira

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• Ohno T

  Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch

• Ohno Tamio

  Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch

• Ohno Tamio

  Department Of Parasitology Hamamatsu University School Of Medicine

• Namikawa T

  Nagoya Univ. Nagoya Jpn

• Namikawa Takao

  名古屋大学 生命農学研究科動物遺伝制御学

• Namikawa Takao

  Laboratory Of Animal Genetics Department Of Applied Molecular Biosciences Graduate School Of Bioagri

• Namikawa Takao

  Laboratry Of Animal Genetics Division Of Applied Genetics And Physiology

• MATSUURA Ayuko

  Laboratry of Animal Genetics, Division of Applied Genetics and Physiology

• MATSUSHIMA Toshiya

  Laboratory of Animal Information Biology, Division of Biofunction Development, Graduate School of Bi

• Matsuura Ayuko

  Laboratry Of Animal Genetics Division Of Applied Genetics And Physiology

• Ishikawa A

  Department Of Orthopaedic Surgery Yamagata University School Of Medicine

• Matsushima Toshiya

  Laboratory Of Animal Information Biology Division Of Biofunction Development Graduate School Of Bioa

• Ishikawa Akira

  Laboratory Of Animal Genetics Division Of Applied Genetics And Physiology Graduate School Of Bioagri

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