Quantitative Trait Loci for Glomerulosclerosis, Kidney Weight and Body Weight in the Focal Glomerulosclerosis Mouse Model
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概要
- 論文の詳細を見る
In 183 male progeny derived from a backcross between the FGS/Kist strain, a new mouse model for focal glomerulosclerosis (FGS) in humans, and the standard normal strain, C57BL/6J, we performed a genome-wide scan for quantitative trait loci (QTLs) affecting the glomerulosclerosis index (GSI) based on histological observation as well as kidney and body weights. Two QTLs for GSI (Gsi1-2) located on chromosomes (Chrs) 8 and 10, a kidney weight QTL (Kdw1) on Chr 19, and a body weight QTL (Bdw1) on Chr 13 were detected at the genome-wide 5% or less level. The allele derived from FGS/Kist increased GSI at Gsi1, but decreased it at Gsi2. The mice homozygous for the FGS/Kist allele decreased body and kidney weights. The identified QTLs accounted for 5-8% of the phenotypic variance.
- 社団法人 日本実験動物学会の論文
著者
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Lee Chul-ho
韓国
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Lee C‐h
Genetic Resources Center Korea Research Institute Of Bioscience And Biotechnology (kribb)
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HYUN Byung-Hwa
ICLAS Monitoring Subcenter Korea, Korea Research Institute of Bioscience and Biotechnology
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KIM Eun-Hee
Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University
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LEE Chul-Ho
Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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HYUN Byung-Hwa
Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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SUH Jun-Gyo
Department of Medical Genetics/Experimental Animal Center, College of Medicine, Hallym University
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OH Yang-Seok
Department of Medical Genetics/Experimental Animal Center, College of Medicine, Hallym University
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NAMIKAWA Takao
Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University
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ISHIKAWA Akira
Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University
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Suh Jun-gyu
韓国
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Lee C‐h
Electrotechnical Lab. Tsukuba
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Lee Chul-ho
Genetic Resources Center Korea Research Institute Of Bioscience And Biotechnology (kribb)
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Lee C‐h
Aist Central 2
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Lee Chul-ho
Energy Electronics Institute National Institute Of Advanced Industrial Science And Technology (aist)
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Kim Eun-hee
Genetic Resources Center Korea Research Institute Of Bioscience And Biotechnology (kribb)
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Namikawa T
Nagoya Univ. Nagoya Jpn
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Namikawa Takao
Laboratory Of Animal Genetics Graduate School Of Bioagricultural Sciences Nagoya University
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Namikawa Takao
Laboratory Of Animal Genetics Department Of Applied Molecular Biosciences Graduate School Of Bioagri
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Namikawa Takao
Laboratry Of Animal Genetics Division Of Applied Genetics And Physiology
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Oh Yang-seok
Department Of Medical Genetics And Experimental Animal Center College Of Medicine Hallym University
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Hyun B‐h
Korea Res. Inst. Biosci. And Biotechnol.(kribb) Taejon Kor
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Hyun Byung-hwa
Genetic Resources Center Korea Research Institute Of Bioscience And Biotechnology (kribb)
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Oh Yang-seok
Department Of Medical Genetics/experimental Animal Center College Of Medicine Hallym University
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Lee Chul-ho
Iclas Monitoring Subcenter Korea Korea Res. Inst. Of Bioscience And Biotechnology
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Hyun Byung-hwa
Genetic Resources Center Korea Research Institute Of Bioscience & Biotechnology
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Ishikawa Akira
Laboratory Of Animal Genetics Division Of Applied Genetics And Physiology Graduate School Of Bioagri
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Ishikawa Akira
Laboratory Of Animal Genetics Graduate School Of Bioagricultural Sciences Nagoya University
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