Bestatin Analogue from Streptomyces neyagawaensis SL-387

概要

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A bestatin analogue, (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-valine (AHPA-Val), from the culture filtrate of Streptomyces neyagawaensis SL-387 was obtained in a chemically defined medium containing DL-3-amino-3-phenylpropionic acid. AHPA-Val was 6 times (IC_<50>=1.2 μg/ml) as strong as bestatin (IC_<50>=7.0 μg/ml) against porcine kidney microsomal aminiopeptidase N, and 4 times (5.6 μg/ml) as strong as bestatin (IC_<50>=20.7 μg/ml) against amino-peptidase N of human metastatic fibrosarcoma HT1080. To the best of our knowledge, this is the first report on the microbial production of AHPA-Val.
社団法人日本農芸化学会の論文
1996-05-23