Changes of Renal Lesion-Related Parameters in FGS/Nga and the Parental Mouse Strains, CBA/N and RFM/Nga

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概要

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• The FGS/Nga mouse strain, established from an outcross between CBA/N and RFM/Nga mice strains, has previously been reported as a spontaneous mouse model for focal glomerular sclerosis (FGS) and is considered to have two pairs of autosomal recessive genes associated with FGS. In this study, we examined the changes of seven renal lesion-related parameters, blood urea nitrogen (BUN), creatinine, albumin and total protein in plasma, urinary protein, systolic blood pressure, and a glomerulosclerosis index on histological observation, in 20-week-old FGS/Nga mice and their age-matched two parental strains, CBA/N and RFM/Nga. The levels of plasma BUN and creatinine, urinary protein and systolic blood pressure were significantly increased in FGS/Nga, compared with those of the parental strains. RFM/Nga mice showed slightly elevated levels of all biochemical makers. In histological analysis, a higher glomerulosclerosis index was observed in FGS/Nga than the two parental strains. RFM/Nga mice appeared to have slight sclerotic lesions of glomeruli, but no renal failure was observed in CBA/N mice. These results suggest that at least one mutant gene that causes the progression of renal lesion in FGS/Nga mice is derived from RFM/Nga.

• 社団法人　日本実験動物学会の論文

著者

• Lee Chul-ho

  韓国

• Lee C‐h

  Genetic Resources Center Korea Research Institute Of Bioscience And Biotechnology (kribb)

• HYUN Byung-Hwa

  ICLAS Monitoring Subcenter Korea, Korea Research Institute of Bioscience and Biotechnology

• CHOI Yang-Kyu

  College of Veterinary Medicine, Konkuk University

• KIM Eun-Hee

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• LEE Chul-Ho

  Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)

• HYUN Byung-Hwa

  Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)

• SUH Jun-Gyo

  Department of Medical Genetics/Experimental Animal Center, College of Medicine, Hallym University

• NAMIKAWA Takao

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• ISHIKAWA Akira

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• KIM Eun-Hee

  Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)

• CHOI Kwang-Soo

  Department of Animal Science and Biotechnology College of Agriculture Kyungpook National University

• LEE Kang-Wook

  Department of Internal Medicine, College of Medicine, Chungnam National University

• SUH Jun-Gyo

  Laboratory Animal Center, College of Medicine, Hallym University

• CHOI Yang-Kyu

  Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)

• Suh Jun-gyu

  韓国

• Suh Jun-gyo

  Laboratory Animal Center College Of Medicine Hallym University

• Lee C‐h

  Electrotechnical Lab. Tsukuba

• Lee Chul-ho

  Genetic Resources Center Korea Research Institute Of Bioscience And Biotechnology (kribb)

• Lee C‐h

  Aist Central 2

• Lee Chul-ho

  Energy Electronics Institute National Institute Of Advanced Industrial Science And Technology (aist)

• Kim Eun-hee

  Genetic Resources Center Korea Research Institute Of Bioscience And Biotechnology (kribb)

• Namikawa T

  Nagoya Univ. Nagoya Jpn

• Namikawa Takao

  Laboratory Of Animal Genetics Graduate School Of Bioagricultural Sciences Nagoya University

• Namikawa Takao

  Laboratory Of Animal Genetics Department Of Applied Molecular Biosciences Graduate School Of Bioagri

• Namikawa Takao

  Laboratry Of Animal Genetics Division Of Applied Genetics And Physiology

• Choi Yang-kyu

  Genetic Resources Center Korea Research Institute Of Bioscience And Biotechnology (kribb)

• Hyun B‐h

  Korea Res. Inst. Biosci. And Biotechnol.(kribb) Taejon Kor

• Hyun Byung-hwa

  Genetic Resources Center Korea Research Institute Of Bioscience And Biotechnology (kribb)

• Lee Kang-wook

  Department Of Internal Medicine College Of Medicine Chungnam National University

• Lee Chul-ho

  Iclas Monitoring Subcenter Korea Korea Res. Inst. Of Bioscience And Biotechnology

• Hyun Byung-hwa

  Genetic Resources Center Korea Research Institute Of Bioscience & Biotechnology

• Ishikawa Akira

  Laboratory Of Animal Genetics Division Of Applied Genetics And Physiology Graduate School Of Bioagri

• Ishikawa Akira

  Laboratory Of Animal Genetics Graduate School Of Bioagricultural Sciences Nagoya University

• Lee Kang-Wook

  Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan

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