Development and Characterization of CATS Markers for Genetic Linkage Mapping in the House Musk Shrew, Suncus murinus

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概要

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• To serve as an initial step in developing an ideal genetic marker map for the house musk shrew, Suncus murinus, 318 comparative anchor tagged sequence (CATS) primer pairs were assessed for polymorphism ascertainment and linkage mapping. Of the 112 (35.2%) CATS primer pairs that were successfully amplified by PCR in the shrew, 18 (16.1%) showed polymorphism between two mutant strains, BAN-kc, oeb and WZ. Linkage analysis of the polymorphic CATS markers and three visible mutant genes, kc, oeb and wz, genotyped in a 77 F2 mapping panel from a cross of the two mutant strains, assigned wz and five CATS markers into three linkage groups. Sequence analysis revealed that two (ADA and TXN) out of nine CATS amplified sequences had a total of six deletions of varying sizes and 17 single nucleotide polymorphisms (SNPs). BLAST search identified three CATS (ADA, CYP1A2, and TXN) products matching the genes from which they were originally designed, while the remaining six markers could not be identified. Together with the use of the detected SNPs as genetic markers, the five CATS markers linkage mapped in this species will serve as anchors in establishing the first framework map for locating loci affecting all heritable qualitative and quantitative traits in the musk shrew.

• 社団法人　日本実験動物学会の論文
• 2005-04-01

著者

• NAMIKAWA Takao

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• ISHIKAWA Akira

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• Namikawa Takao

  Graduate School Of Bioagricultual Sciences Nagoya University

• Namikawa Takao

  Laboratory Of Animal Genetics Department Of Applied Molecular Biosciences Graduate School Of Bioagri

• KOBAYASHI EIJI

  Department of Biotechnology, Graduate School of Engineering

• ADJEI Samuel

  Laboratory of Animal Genetics, Department of Applied Molecular Biosciences, Graduate School of Bioag

• SATO Akira

  Laboratory of Animal Genetics, Department of Applied Molecular Biosciences, Graduate School of Bioag

• TANAKA Shigekazu

  Laboratory of Animal Genetics, Department of Applied Molecular Biosciences, Graduate School of Bioag

• TANAKA Kazuaki

  Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University

• Adjei Samuel

  名古屋大学 大学院生命農学研究科応用遺伝･生理学講座

• Kobayashi Eiji

  Department Obstetrics And Gynecology Osaka Rosai Hospital

• Adjei Samuel

  Laboratory Of Animal Genetics Department Of Applied Molecular Biosciences Graduate School Of Bioagri

• Kobayashi Eiji

  Department Of Technology National Livestock Breeding Centre

• Tanaka Shigekazu

  Laboratory Of Animal Genetics Department Of Applied Molecular Biosciences Graduate School Of Bioagri

• Tanaka Kazuaki

  Department Of Animal Science And Biotechnology School Of Veterinary Medicine Azabu University

• Ishikawa Akira

  Division Of Applied Genetics And Physiology Graduate School Of Bioagricultural Sciences Nagoya Unive

• Ishikawa Akira

  Laboratory Of Animal Genetics Division Of Applied Genetics And Physiology Graduate School Of Bioagri

• Sato Akira

  Laboratoire De Chimie Du Solide Du Cnrs Universite Bordeaux I

• Sato Akira

  Laboratory Of Animal Genetics Department Of Applied Molecular Biosciences Graduate School Of Bioagri

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