小型精巣突然変異マウス(Smt)の精子形成異常及び小型精巣に関与するQTLsの検出

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概要

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• The small testis (Smt) mutant mouse is characterized by a small testis of one third to one half the size of a normal testis, and its spermatogenesis is mostly arrested at early stages of meiosis, although a small number of spermatocytes at the late prophase of meiosis and a few spermatids can sometimes be seen. We performed quantitative trait locus (QTL) analysis of these spermatogenic traits and testis weight using 221 F2 males obtained from a cross between Smt and MOM (Mus musculus molossinus) mice. At the genome-wide 5% level, we detected two QTLs affecting meiosis on chromosomes 4 and 13, and two QTLs for paired testis weight as a percentage of body weight on chromosomes 4 and X. In addition, we found several QTLs for degenerated germ cells and multinuclear giant cells on chromosomes 4, 7 and 13. Interestingly, for cell degeneration, the QTL on chromosome 13 interacted epistatically with the QTL on chromosome 4. These results reveal polygenic participation in the abnormal spermatogenesis and small testis size in the Smt mutant.

• 社団法人　日本実験動物学会の論文
• 2006-04-01

著者

• ISHIKAWA Akira

  Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine

• Zhao Wei

  Laboratory Of Animal Genetics And Breeding Department Of Animal Science College Of Animal Husbandry

• Wakasugi Noboru

  Division Of Applied Genetics And Physiology Graduate School Of Bioagricultural Sciences Nagoya Unive

• BOLOR Hasbaira

  Division of Applied Genetics and Physiology, Graduate School of Bioagricultural Sciences, Nagoya Uni

• Bolor Hasbaira

  Division Of Applied Genetics And Physiology Graduate School Of Bioagricultural Sciences Nagoya Unive

• Ishikawa Akira

  Division Of Applied Genetics And Physiology Graduate School Of Bioagricultural Sciences Nagoya Unive

• 若杉 昇

  Division of Applied Genetics and Physiology, Graduate School of Bioagricultural Sciences, Nagoya University

• 趙 衛東

  Laboratory of Animal Genetics and Breeding, Department of Animal Science, College of Animal Husbandry and Veterinary Medicine, Henan Agricultural University

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• 小型精巣突然変異マウス(Smt)の精子形成異常及び小型精巣に関与するQTLsの検出
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