Developing a New Model for Non-Insulin Dependent Diabetes Mellitus (NIDDM) by Using the Philippine Wild Mouse, Mus musculus castaneou

スポンサーリンク

概要

• 論文の詳細を見る

• The Philippine wild-caught castaneus mouse (Mus musculus castaneus) and laboratory mouse (C57BL/6J: B6) were used to develop a new non-insulin dependent diabetes mellitus (NIDDM) model. Offspring from the cross between a wild male and B6 female were backcrossed to the sire. One male which exhibited highest fasting hyperglycemia (190 mg/dl) among eighty-seven backcross offspring was selected at 10 weeks of age, and crossed with a B6 female to comprise the fundamental stock (F0). Thereafter, full-sib mating was performed to develop a new inbred strain named CBD (Castaneus-B6 diabetic) mouse. Mice with relatively higher fasting hyperglycemia among F0 and F1 generations were selected for breeding. From the F2 generation, mice were defined as diabetic when blood glucose levels exceeded 200 mg/dl at 120 min in intraperitoneal glucose tolerance test (IPGTT) at 10 weeks of age, and have been selectively bred. The incidence of diabetic males from the F3-F6 generation fluctuated 45-75% at 10 weeks of age and 59-72% at 20 weeks of age. Diabetic males had about two-fold higher fasting glucose and insulin levels than B6 males. Glucose-stimulated insulin secretion was impaired in diabetic CBD mice compared to B6 males at 20 weeks. Moreover, diabetic mice had slight obesity compared to B6 mice. These facts indicated that diabetic features of CBD mice resemble NIDDM in humans. The CBD strain, characterized by high incidence and early onset of diabetes with mild obesity would be of value as a new NIDDM model. The method, utilizing wild castaneus mouse of different origin from laboratory mice, maybe useful in the development of other animal models.

• 社団法人　日本実験動物学会の論文

著者

• NAMIKAWA Takao

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• HORIO Fumihiko

  Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University

• Ohno T

  Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch

• Ohno Tamio

  Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch

• Ohno Tamio

  Department Of Parasitology Hamamatsu University School Of Medicine

• Horio F

  Nagoya Univ. Nagoya Jpn

• Horio Fumihiko

  Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive

• Namikawa T

  Nagoya Univ. Nagoya Jpn

• Namikawa Takao

  名古屋大学 生命農学研究科動物遺伝制御学

• Namikawa Takao

  Laboratory Of Animal Genetics Department Of Applied Molecular Biosciences Graduate School Of Bioagri

• Namikawa Takao

  Laboratry Of Animal Genetics Division Of Applied Genetics And Physiology

• ANUNCIADO Rea

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University.

• IMAMURA Tsunehiko

  Division of Biomodelling, Graduate School of Bioagricultural Sciences, Nagoya University

• Anunciado Rea

  Laboratory Of Animal Genetics Graduate School Of Bioagricultural Sciences Nagoya University.

• Imamura Tsunehiko

  Division Of Biomodelling Graduate School Of Bioagricultural Sciences Nagoya University

関連論文

• A Morphometric Study of the Adrenal Cortex of the Female DDD Mouse(Anatomy)
• Quantitative Trait Loci for Glomerulosclerosis, Kidney Weight and Body Weight in the Focal Glomerulosclerosis Mouse Model
• Changes of Renal Lesion-Related Parameters in FGS/Nga and the Parental Mouse Strains, CBA/N and RFM/Nga
• Differential Development of Sex-related Characters of Chickens from the GSP and PNP/DO Inbred Lines after Left Ovariectomy
• Production of Recombinant Chicken IgY-Fc and Evaluation of Its Transport Ability into Avian Egg Yolks
• Diabetic Cataract of the Musk Shrew (Suncus murinus, Insectivora) Exhibiting Spontaneous Non-Insulin Dependent Diabetes Mellitus (NIDDM)
• Blood and Liver Lipid Concentrations in EDS Shrews Exhibiting Spontaneous Non-Insulin Dependent Diabetes Mellitus (NIDDM)
• Open Eyelids at Birth, a New Mutation in the Musk Shrew, Suncus murinus
• Delayed Development of Reflexes and Hyperactive Locomotion in the Spontaneous Mutant "Waltzing" of the Musk Shrew, Suncus murinus
• Mitochondrial diversity of native pigs in the mainland South and South-east Asian countries and its relationships between local wild boars
• Development and Characterization of CATS Markers for Genetic Linkage Mapping in the House Musk Shrew, Suncus murinus
• Sequence variation and evolution of the mitochondrial DNA control region in the musk shrew, Suncus murinus
• Mapping major quantitative trait loci for postnatal growth in an intersubspecific backcross between C57BL/6J and Philippine wild mice by using principal component analysis
• Quantitative Trait Locus Analysis of Serum Insulin, Triglyceride, Total Cholesterol and Phospholipid Levels in the (SM/J×A/J)F_2 Mice
• Quantitative Trait Loci for Body Weight in the Intercross between SM/J and A/J Mice
• Distribution of Body Weight, Blood Insulin and Lipid Levels in the SMXA Recombinant Inbred Strains and the QTL Analysis
• Characterization of Hyperinsulinemic Recombinant Inbred (RI) Strains (SMXA-5 and SMXA-9) Derived from Normoinsulinemic SM/J and A/J Mice
• Developing a New Model for Non-Insulin Dependent Diabetes Mellitus (NIDDM) by Using the Philippine Wild Mouse, Mus musculus castaneou
• Confirmation of Diabetes-Related Quantitative Trait Loci Derived from SM/J and A/J Mice by Using Congenic Strains Fed a High-Carbohydrate or High-Fat Diet
• The Eye Lens Aplasia (elap) Maps to Mouse Chromosome 2
• The novel polymorphism of the beta 3-adrenergic receptor gene and its distribution in domestic pigs and wild boars in Asia
• ニワトリ近交系GSP,GSN/1,PNP/どおよびBM-C系における,赤血球抗原変異検索,リンパ球混合培養法および皮膚移植法による主要組織適合遺伝子複合体抗原の均一性の評価
• Increase in Oxidative Stress in Kidneys of Diabetic Akita Mice(Food & Nutrition Science)
• Cyanidin 3-O-β-D-Glucoside Attenuates the Hepatic Ischemia-Reperfusion Injury through a Decrease in the Neutrophil Chemoattractant Production in Rats
• Determination of Immunoglobulin Y Concentration in Yolk Extract Prepared by Water Dilution Method : Comparisons among Three Strains of Chickens
• A/J-11[SM]コンソミックマウスの体重と主要器官重量
• Ascorbic Acid Deficiency Stimulates Hepatic Expression of Inflammatory Chemokine, Cytokine-Induced Neutrophil Chemoattractant-1, in Scurvy-Prone ODS Rats
• Serum Adiponectin Concentration : Its Correlation with Diabetes-Related Traits and Quantitative Trait Loci Analysis in Mouse SMXA Recombinant Inbred Strains
• SMXA-5 Mouse as a Diabetic Model Susceptible to Feeding a High-fat Diet
• Characteristics of Ascorbic Acid Metabolism in Scurvy-Prone Spontaneously Hypertensive Rat, SHR-od
• Characteristics of Ascorbic Acid Metabolism in Scurvy-Prone Spontaneously Hypertensive Rat, SHR-od
• Cyanidin 3-O-β-D-glucoside Suppresses Nitric Oxide Production during a Zymosan Treatment in Rats
• A Low Protein Diet Increases 4-Nitrophenol-UDPglucuronosyltransferase but Decreases Chloramphenicol-UDPglucuronosyltransferase Activity and mRNA Level in Livers of Rats Treated with Polychlorinated Biphenyls
• BALB/cマウスにおけるX層の形態とa(agouti)遺伝子座の変異との遺伝的関連
• Bone Mineral Analysis through Dual Energy X-Ray Absorptiometry in Laboratory Animals
• Genetic analysis of mortality in murine angiostrongyliasis costaricensis using SMXA recombinant inbred mouse strains
• Red jungle fowl (Gallus gallus) as a model for studying the molecular mechanism of seasonal reproduction
• Milk protein polymorphisms in cattle (Bos indicus), mithun (Bos frontalis) and yak (Bos grunniens) breeds and their hybrids indigenous to Bhutan
• Microscopic detection of IgY-Fc binding signal in the inner layers of ovarian follicular tissue in quail
• Cyanidin 3-O-β-D-glucoside Suppresses Nitric Oxide Production during a Zymosan Treatment in Rats
• Genetic variation and geographic distribution on the mitochondrial DNA in local populations of the musk shrew, Suncus murinus
• Coffee and Caffeine Improve Insulin Sensitivity and Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
• Molecular phylogeny and diversity of Myanmar and Bhutan mithun based on mtDNA sequences
• Polymorphisms in the bovine hemoglobin-beta gene provide evidence for gene-flow between wild species of Bos (Bibos) and domestic cattle in Southeast Asia
• Changes of Estrous Cycles with Aging in Female F344/N Rats
• Morphometric Comparison of the Rat Mandible in F344 Substrains, F344/Du and F344/N

もっと見る 閉じる

スポンサーリンク