ニワトリ近交系GSP,GSN/1,PNP/どおよびBM-C系における,赤血球抗原変異検索,リンパ球混合培養法および皮膚移植法による主要組織適合遺伝子複合体抗原の均一性の評価

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概要

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• Chicken inbred lines of the GSP, GSN/1, PNP/DO and BM-C have been established by selection of a specific allele at the B blood group locus (MHC B-G region) and other polymorphic loci through pedigree mating. To extend the potential of these inbred lines as experimental animals in Aves, we assessed the antigenic homogeneities of the MHC antigens by three immunological methods. Antigenic variations of red blood cells (RBCs) were surveyed in the inbred lines and a random-bred line (NG) derived from the Nagoya breed by using ten kinds of intact antisera produced in the inbred line of chickens against RBCs of a red junglefowl and hybrids. In the hemagglutination test, no individual variations were found within the inbred line at all, while all the ten antisera detected highly heterogeneous reactions in individuals of the NG. The reciprocal one-way mixed lymphocyte reactions gave constantly higher stimulation responses (P<0.01) between individual pairs from the inbred lines having different B alleles compared to pairs within the inbred line, while lower stimulation was observed between pairs of the GSP and GSN/1 inbred lines both having the B21 allele. In reciprocal skin transplantation, the transplanted skingrafts within the inbred line and between individuals from the GSP and GSN/1 inbred lines survived more than 100 days, while all the skingrafts showed signs of rejection within 7 days among the inbred lines having different B alleles. The results obtained by the three practical methods coincidentally indicated that the individuals in the respective four inbred lines were histocompatible, and further, that the GSP and GSN/1 individuals were histocompatible.

• 社団法人　日本実験動物学会の論文

著者

• NAMIKAWA Takao

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• FUJIWARA Akira

  Laboratory Animal Research Station, Nippon Institute for Biological Science

• YAZAWA Hajime

  Laboratory Animal Research Station, Nippon Institute for Biological Science

• YAMAGATA Takahiro

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• VALDEZ Jr

  Laboratory of Animal Science, College of Agriculture, Kochi University

• Namikawa Takao

  Laboratory Of Animal Genetics Department Of Applied Molecular Biosciences Graduate School Of Bioagri

• 藤原 哲

  財団法人日本生物科学研究所

• SHIMADA Kiyoshi

  Laboratory of Animal Physiology, Graduate School of Bioagricultural Sciences, Nagoya University

• Mizutani Makoto

  Laboratory Animal Research Station, Nippon Institute of Biological Science

• 水谷 誠

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• 藤原 哲

  Laboratory Animal Research Station, Nippon Institute for Biological Science

• Fujiwara Akira

  Laboratory Animal Research Station Nippon Institute For Biological Science

• Yazawa Hajime

  Laboratory Animal Research Station Nippon Institute For Biological Science

• VALDEZ Jr.

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

• Mizutani Makoto

  Laboratory Animal Research Station Nippon Institute For Biological Science

• Yamagata Takahiro

  Laboratory Of Animal Genetics Graduate School Of Bioagricultural Sciences Nagoya University

• Shimada Kiyoshi

  Laboratory Of Animal Physiology Division Of Applied Genetics And Physiology Applied Molecular Biosci

• MIZUTANI Makoto

  Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

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