マウス第12染色体上の成長QTL Pbwg12を導入したコンジェニック系統の樹立と特徴解析
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概要
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In previous genome-wide QTL studies, Pbwg12 on mouse chromosome 12 was discovered in a gene pool of wild Mus musculus castaneus mice. Pbwg12 does not have a main effect but has an epistatic interaction effect on body weight after birth. In this study, we developed a congenic strain, named B6.Cg-Pbwg12, with an approximately 59-Mb wild-derived genomic region harboring Pbwg12, by recurrent backcrossing to C57BL/6J. A phenotypic comparison between B6.Cg-Pbwg12 and C57BL/6J revealed that Pbwg12 does not have any main effects on body weight at 1-10 weeks of age but has a main effect on body weight gain at 6-10 weeks. A new QTL with a male-specific effect on kidney weight was discovered within the introgressed region.
著者
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Li Chun
Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural Un
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ISHIKAWA Akira
Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University
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石川 明
Laboratory of Animal Genetics, School of Agricultural Sciences, Nagoya University
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李 春
Laboratory of Animal Genetics, Division of Applied Genetics and Physiology, Graduate School of Bioag
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