Mapping of the beige(bg) Gene on Rat Chromosome 17
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概要
- 論文の詳細を見る
The rat beige (bg) autosomal recessive gene, causing Chediak-Higashi Syndrome (CHS) in rat, was mapped on Chr 17 by using synteny of rat to mouse and humans. The linkage between the beige gene and PCR-amplified microsatellite markers in (DA-bg × BN)F 1 × DA-bg backcross progeny was analysed. The recombination frequency was 9.5% between Prl and Acrm and 19.1% between Acrm and bg. The proposed order of three genes is Prl-Acrm-bg. This rat bg gene was confirmed to be homologus to the beige (bg) gene of mouse located on Chr 13 and the CHS (Lyst) gene of man located on Chr 1 (1q43).
- 社団法人 日本実験動物学会の論文
著者
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NISHIKAWA Tetsu
Institute for Experimental Animals, Hamamatsu University School of Medicine
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Nishikawa Tetsu
Institute For Experimental Animals Hamamatsu University School Of Medicine
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NISHIMURA Masahiko
Institute for Laboratory Animal Research, Nagoya University School of Medicine
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Nishimura M
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Nishimura Masahiko
Institute For Experimental Animals Hamamatsu University School Of Medicine
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Nishimura Masahiko
Division Of Experimental Animals Center For Promotion Of Medical Research And Education Graduate Sch
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Nishikawa T
Institute For Experimental Animals Hamamatsu University School Of Medicine
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