mRNA Expression and cDNA Sequences of β- and γ-Sarcoglycans Are Normal in Cardiomyopathic Hamster Heart
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概要
- 論文の詳細を見る
In BIO14.6 cardiomyopathic hamster heart, the dystrophin-glycoprotein complex is disrupted and sarcoglycans are greatly reduced in abundance. We examined whether the gene expression of β- and γ-sarcoglycans is indeed defective in this hamster. We found that mRNA expression for these proteins and the cDNA sequences of their coding regions are identical in both normal and myopathic hamster cardiomyocytes. The results strongly suggest that defect in a currently unknown sarcoglycan-associated protein(s) is responsible for the deficiency of the sarcoglycan complex that leads to muscle cell necrosis in the myopathic hamster.
- 公益社団法人日本薬学会の論文
- 1997-02-15
著者
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SHIGEKAWA Munekazu
Department of Melecular Physiology, National Cardiovascular Center Research Institute
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NISHIMURA Masahiko
Institute for Laboratory Animal Research, Nagoya University School of Medicine
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Hanada Hironori
Department Of Molecular Physiology National Cardiovascular Center Research Institute
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Hanada Hironori
国立循環器病センター
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Iwata Yuko
Department Of Molecular Physiology National Cardiovascular Center Research Institute
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Nishimura Masahiko
Institute For Experimental Animals Hamamatsu University School Of Medicine
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YOSHIDA Tomokazu
Department of Molecular Physiology, National Cardiovascular Center Research Institute
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PAN Yan
Department of Molecular Physiology, National Cardiovascular Center Research Institute
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Pan Yan
Department Of Molecular Physiology National Cardiovascular Center Research Institute
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Pan Yan
Department Of Animal Physiology Faculty Of Biology University Of Warmia And Mazury
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Shigekawa M
National Cardiovascular Center Res. Inst. Osaka Jpn
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Yoshida Tomokazu
Department Of Molecular Physiology National Cardiovascular Center Research Institute
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Shigekawa Munekazu
Department Of Food And Nutrition Faculty Of Human Life Sciences Senri Kinran University
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Hanada Hironori
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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