Impaired Thermoregulatory Ability of Oxytocin-Deficient Mice during Cold-Exposure
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概要
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We analyzed temperature homeostasis in oxytocin-deficient (Oxt−⁄−) mice and found that Oxt−⁄− mice exhibited lower body temperatures than wild-type animals when they were exposed to cold. Oxt−⁄− mice also showed slightly more weight gain, but there were no obvious differences in the morphology of white and brown adipose tissues as between wild-type and Oxt−⁄− mice. In cold-exposed conditions, oxytocin neurons containing c-Fos immunoreactivity existed in the paraventricular nucleus of the hypothalamus.These results suggest that the central oxytocin neurons constitute part of the thermoregulatory system involved in maintaining body temperature in cold environments.
- 2007-12-23
著者
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Itoi Keiichi
Laboratory Of Information Biology Graduate School Of Information Sciences Tohoku University
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Nishimori Katsuhiko
Laboratory Of Molecular Biology Department Of Molecular And Cell Biology Graduate School Of Agricult
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Kawada Teruo
Laboratory For Molecular Function Of Food Division Of Food Science And Biotechnology Graduate School
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Kawada Teruo
Laboratory Of Molecular Function Of Food Division Of Food Science And Biotechnology Graduate School
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Kasahara Yoshiyuki
Lab. Of Molecular Biology Dep. Of Molecular And Cell Biology Graduate School Of Agricultural Sci. To
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Kasahara Yoshiyuki
Laboratory Of Molecular Biology Department Of Molecular And Cell Biology Graduate School Of Agricult
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TAKAYANAGI Yuki
Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricu
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Takayanagi Yuki
Laboratory Of Molecular Biology Department Of Molecular And Cell Biology Graduate School Of Agricult
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