LGR4 Is Required for the Cell Survival of the Peripheral Mesenchyme at the Embryonic Stages of Nephrogenesis

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概要

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• In mice, homozygous Lgr4 inactivation results in hypoplastic kidneys. To understand better the role of LGR4 in kidney development, we performed an analysis of kidneys in Lgr4-/- embryos. We stained Lgr4-/- kidneys with anti-WT1 and anti-Cleaved Caspase3 antibodies at E16.5, and observed that the structures of the cap mesenchyme were disrupted and that apoptosis increased. In addition, the expression of PAX2, an anti-apoptotic factor in kidney development, was also significantly decreased at E16.5. We found that the LGR4 defect caused an increase in apoptosis in the peripheral mesenchyme during kidney development.

• 2012-05-23

著者

• Nishimori Katsuhiko

  Laboratory Of Molecular Biology Department Of Molecular And Cell Biology Graduate School Of Agricult

• Nishimori Katsuhiko

  Laboratory Of Molecular Biology Department Of Molecular And Cell Biology Graduate School Of Agricult

• Mohri Yasuaki

  Laboratory Of Molecular Biology Graduate School Of Agricultural Science Tohoku University

• Akamatsu Atsushi

  Laboratory Of Molecular Biology Graduate School Of Agricultural Science Tohoku University

• Sone Mizuki

  Laboratory Of Molecular Biology Graduate School Of Agricultural Science Tohoku University

• OYAMA Kazunori

  Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University

• Oyama Kazunori

  Laboratory Of Molecular Biology Graduate School Of Agricultural Science Tohoku University

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• LGR4 Is Required for the Cell Survival of the Peripheral Mesenchyme at the Embryonic Stages of Nephrogenesis
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