Stimulatory Effects of Prostaglandin E2 on Neurogenes in the Dentate Gyrus of the Adult Rat : Neurobiology
スポンサーリンク
概要
- 論文の詳細を見る
Neurogenesis in the dentate gyrus of adult rodents is elicited by transient global ischemia. Cyclooxygenase (COX) -2, a rate-limiting enzyme for prostanoid synthesis, is also induced by ischemia. We recently found that the administration of a non-selective COX inhibitor to ischemic animals suppressed cell proliferation in the subgranular zone (SGZ) at the dentate gyrus of the hippocampus. To clarify whether prostaglandin E2 (PGE2) synthesis by COX's is involved in neurogenesis, sulprostone, an analogue of PGE2, was injected into the rat hippocampus. Sulprostone injection increased the number of 5-bromo-2'-deoxyuridine (BrdU)-positive cells in the SGZ. BrdU-positive cells also expressed polysialylated isoforms of neural cell adhesion molecule and neuronal nuclear antigen. These results suggest that PGE2 plays an important role in the proliferation of cells in the SGZ.
- 社団法人日本動物学会の論文
- 2002-11-25
著者
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Kobayashi Tetsuya
埼玉大学 理学部生体制御学科
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Kobayashi Tetsuya
Department Of Regulation Biology Faculty Of Science Saitama University
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MACHIDA Takeo
Department of Regulation Biology, Faculty of Science, Saitama University
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Machida Takeo
埼玉大学 理学部生体制御学科
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Machida Takeo
Department Of Regulation Biology Graduate School Of Fisheries Science And Engineering Saitama Univer
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Machida Takeo
Deparatment Of Regulation Biology Faculty Of Science Saitama University
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Machida Takeo
Graduate School Of Science And Engineering Saitama University
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Kobayashi Tetsuya
Laboratory Of Integrative Brain Sciences Department Of Biology Faculty Of Education And Integrated A
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ITOI Keiichi
Laboratory of Molecular Endocrinology Tohoku University Graduate School of Medicine
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Itoi Keiichi
Division Of Information Biology Graduate School Of Information Sciences Tohoku University
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Itoi Keiichi
Laboratory Of Information Biology Graduate School Of Information Sciences Tohoku University
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Kumihashi Kentarou
Department of Regulation Biology, Graduate School of Fisheries Science and Engineering, Saitama Univ
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Uchida Katsuya
Department of Regulation Biology, Graduate School of Science and Engineering, Saitama University
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Kurosawa Satoshi
Department of Regulation Biology, Graduate School of Science and Engineering, Saitama University
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Kobayashi Tetsuya
Deparatment Of Regulation Biology Faculty Of Science Saitama University
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Uchida K
Graduate School Of Information Sciences Tohoku University
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Kobayashi T
Department Of Regulation Biology Faculty Of Science Saitama University
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Uchida Katsuya
Department Of Biology Faculty Of Science Toyama University
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Kumihashi Kentarou
Department Of Regulation Biology Graduate School Of Fisheries Science And Engineering Saitama Univer
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Kurosawa S
Department Of Regulation Biology Graduate School Of Science And Engineering Saitama University
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Kurosawa Satoshi
Department Of Chemistry Science University Of Tokyo
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Machida T
Division Of Life Science Graduate School Of Science And Engineering Saitama University
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