Responses of the Thyroid Gland to TSH and Other Thyroid Stimulators in the Growth-Retarded (grt) Mouse(Endocrinology)
スポンサーリンク
概要
- 論文の詳細を見る
The growth-retarded (grt) mouse, originally isolated from a closed colony of Snell's dwarf mouse (DW/J strain), shows growth retardation that is inherited in a recessive manner. We have already reported that this strain exhibits severe primary hypothyroidism with significantly reduced plasma levels of thyroxine (T_4), dramatically elevated plasma liters of thyroid-stimulating hormone (TSH) and an increase in the number of immunoreactive TSH cells in the pituitary gland. The thyroid gland of the grt mouse exhibits characteristically numerous smaller follicles with poor colloid accumulation. In order to elucidate the possible site of the defect in the grt mouse, and in particular to clarify the discrepancy between elevated plasma TSH titers and reduced T_4 levels, we examined the bioactivity of TSH recovered from the plasma sample of the grt animal and the responses of the grt thyroid gland to exogenous TSH and other thyroid hormone secretagogues. Plasma samples from the grt mice invariably exhibited significant levels of TSH bioactivity following injection into normal test mice. Thus, the reduced responsiveness to TSH exhibited by the grt mice is not due to the reduced bioactivity of TSH. Administration of exogenous TSH to the grt mice failed to elevate the plasma T_4 and triiodothyronine (T_3) levels in vivo or to stimulate free T_4 and free T_3 releases from the grt thyroid gland in vitro. The thyroid gland of the grt mouse exhibited a markedly diminished response of adenylate cyclase to exogenous TSH as compared to the gland of euthyroid littermates. Production of cAMP in the grt mouse was significantly increased following stimulation of the thyroid glands with forskolin, cholera toxin, prostaglandin (PG) E_1 and isoproterenol. These results strongly suggest a defect in TSH responsiveness, particularly in TSH-TSH receptor-Gs protein-adenylate cyclase signalling system including the expression and the function of TSH receptor and the TSH receptor-Gs protein coupling, in the thyroid gland of the grt mice.
- 社団法人日本動物学会の論文
- 2001-09-20
著者
-
Kobayashi Tetsuya
Department Of Regulation Biology Faculty Of Science Saitama University
-
MACHIDA Takeo
Department of Regulation Biology, Faculty of Science, Saitama University
-
Kobayashi Kenichi
National Institute of Industrial Health
-
Yamamoto Hideaki
Department of Regulation Biology, Faculty of Science, Saitama University
-
Machida Takeo
埼玉大学 理学部生体制御学科
-
Machida Takeo
Deparatment Of Regulation Biology Faculty Of Science Saitama University
-
Machida Takeo
Graduate School Of Science And Engineering Saitama University
-
Kobayashi Tetsuya
Laboratory Of Integrative Brain Sciences Department Of Biology Faculty Of Education And Integrated A
-
Kobayashi Keiko
Graduate School Of Science And Technology Niigata University
-
Yamamoto Hideaki
Department Of Electrical Engineering Faculty Of Engineering Science Osaka University
-
Kobayashi Tetsuya
Deparatment Of Regulation Biology Faculty Of Science Saitama University
-
Kobayashi T
Department Of Regulation Biology Faculty Of Science Saitama University
-
Kobayashi Kana
Faculty Of Letters Keio University
-
Kobayashi K
Graduate School Of Humanities And Sciences Nara Women's University
-
Yamamoto Hideaki
Department Of Regulation Biology Faculty Of Science Saitama University
-
Kobayashi K
Department Of Regulation Biology Faculty Of Science Saitama University
関連論文
- INVOLVEMENT OF D2 DOPAMINE RECEPTOR SUBTYPE IN INHIBITION OF PROLACTIN RELEASE FROM THE BULLFROG PITUITARY GLAND
- IDENTIFICATION OF cDNAS ENCODING THYROTROPIN-RELEASING HORMONE RECEPTOR FROM THE BULLFROG
- MECHANISMS OF TRH-INDUCED PRL RELEASE FROM THE BULLFROG PITUITARY GLAND
- A POSSIBLE ROLE OF STEROIDAL SUBSTANCES EXISTING IN THE ABDOMINAL GLAND OF THE MALE NEWT, CYNOPS PYRRHOGASTER(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- OCCURRENCE OF STEROIDAL SUBSTANCES IN THE ABDOMINAL GLAND OF THE NEWT CYNOPS PYRRHOGASTER(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- STUDIES OF GHRELIN-INDUCED GROWTH HORMONE AND PROLACTIN RELEASE FROM THE BULLFROG PITUITARY(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- NOVEL FUNCTION OF fGRP AND fGRP RELATED PEPTIDES : THEIR EFFECTS ON THE RELEASE OF TSH FROM THE BULLFROG PITUITARY(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- FROG GROWTH HORMONE-RELEASING PEPTIDE-RELATED PEPTIDES : ISOLATION, CHARACTERIZATION, AND BIOLOGICAL ACTIVITIES
- IDENTIFICATION AND BIOLOGICAL ACTIVITY OF A FROG GH-RELEASING PEPTIDE-RELATED PEPTIDE(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- EXPRESSION, STRUCTURE AND FUNCTION OF TSH RECEPTOR IN THE THYROID GLAND OF GROWTH-RETARDED MICE
- IDENTIFICATION OF NOVEL HYPOTHALAMIC LPXRF-AMIDE PEPTIDES IN THE VERTEBRATE BRAIN
- CLONING OF A cDNA ENCODING FROG GROWTH HORMONE-RELEASING PEPTIDE (fGRP)
- Responses of the Thyroid Gland to TSH and Other Thyroid Stimulators in the Growth-Retarded (grt) Mouse(Endocrinology)
- IN VITRO RESPONSIVENESS OF THYROID GLANDS TO TSH AND OTHER STIMULATORS OF ADENYLATE CYCLASE IN GROWTH - RETARDED MICE
- RESPONSIVENESS OF THE THYROID GLAND TO TSH AND FORSKOLIN IN GROWTH-RETARDED MICE
- AGE-ASSOCIATED CHANGES IN PLASMA CONCENTRATIONS OF GROWTH HORMONE(GH), PROLACTIN(PRL), THYROID-STIMULATING HORMONE(TSH) AND THYROXINE(T_4) IN THE GROWTH-RETARDED MOUSE
- Occurrence of Octopus GnRH in the Central Nervous System and Peripheral Organs of the Octopus (Octopus vulgaris)
- 鳥類における脳の性分化機構
- ROLE OF THYROID HORMONE ON THE EXPRESSION OF LORDOSIS BEHAVIOR IN THE FEMALE GROWTH-RETARDED MOUSE(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- RELATIONSHIPS BETWEEN GROWTH-RETARDATION AND GLUCOSE HOMEOSTASIS IN THE GROWTH-RETARDED MICE(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- ROLE OF THYROID HORMONES ON THE DEVELOPMENT OF REPRODUCTIVE FUNCTION IN THE GROWTH-RETARDED MICE(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- EFFECTS OF INSULIN ON GROWTH-RETARDATION IN THE grt MICE
- EFFECTS OF THYROID HORMONE ON REGULATION OF BLOOD GLUCOSE LEVEL IN THE GROWTH-RETAEDED MOUSE(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Treatment of giant cell tumors in the sacrum and spine with curettage and argon beam coagulator
- Synthesis and Release of Steroids in Intestines from Cynomolgus Monkeys(Macaca fascicularis)(Endocrinology)
- ENZYME ACTIVITIES RELATED TO TESTOSTERONE METABOLISM IN INTESTINAL TISSUES OF MALE CYNOMOLGUS MONKEYS
- Monitoring the Reproductive Status of Female Gorillas (Gorilla gorilla gorilla) by Measuring the Steroid Hormones in Fecal Samples
- HEMORRHAGIC SHOCK-INDUCED PHOSPHORYLATION OF CRE-BINDING PROTEIN IN THE RAT BRAIN(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- EFFECTS OF PROSTAGLANDIN RECEPTOR STIMULI ON NEUROGENESIS IN THE DENTATE GYRUS OF THE ADULT RAT(Physiology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- NEUROGENESIS OF HIPPOCAMPAL CELLS BY THYROID HORMONE IN THE HYPOTHYROIDAL MUTANT MOUSE(Physiology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- PROLIFERATION OF HIPPOCAMPAL CELLS BY THYROID HORMONE IN THE HYPOTHYROIDAL MUTANT MOUSE
- Stimulatory Effects of Prostaglandin E2 on Neurogenes in the Dentate Gyrus of the Adult Rat : Neurobiology
- Prostaglandin E2 increases the proliferation of granule cell precursors in the dentate gyrus of the adult rat(Physiology)(Proceeding of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- INHIBITORY INPUTS TO THE GRANULE CELLS IN THE HIPPOCAMPUS OF RAT(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Neural Interaction of Gonadotropin-regulating Hormone Immunoreactive Neurons and the Suprachiasmatic Nucleus with the Paraventricular Organ in the Japanese Grass Lizard (Takydromus tachydromoides)(Endocrinology)
- EFFECT OF ESTROGEN AND PROLACTIN ON THE PERCEPTION OF SODEFRIN IN FEMALE NEWTS, Cynops pyrrhogaster
- CHANGES IN SYNAPTIC EFFICIENCY OF HIPPOCAMPAL GRANULE CELLS DURING OPERANT BEHAVIOR IN RATS(Physiology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- GONADOTROPIN-INHIBITORY HORMONE AND ITS RECEPTOR IN THE AVIAN REPRODUCTIVE SYSTEM
- GnIH NEURONS PROJECT TO GnRH NEURONS IN THE AVIAN BRAIN
- CIRCADIAN CHANGE IN THE BIOSYNTHESIS OF 7α-HYDROXYPREGNENOLONE STIMULATING LOCOMOTOR ACTIVITY AND ITS MECHANISM MEDIATED BY MELATONIN IN THE BRAIN OF MALE QUAIL
- SEX DIFFERENCE IN THE SYNTHESIS OF 7α-HYDROXYPREGNENOLONE IN THE BRAIN OF BREEDING NEWTS
- GONADOTROPES EXPRESS THE RECEPTOR FOR GONADOTROPIN-INHIBITORY HORMONE (GNIH) IN QUAIL
- IDENTIFICATION AND FUNCTION OF 7α-HYDROXYPREGNENOLONE IN THE BRAIN OF RANA NIGROMACULATA(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- SEX DIFFERENCE IN THE EXPRESSION OF Ad4BP/SF-1 IN THE QUAIL BRAIN(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- NOVEL HAMSTER HYPOTHALAMIC LPXRFA PEPTIDES STIMULATE LH RELEASE(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- GONADOTROPIN-INHIBITORY HORMONE INHIBITS GONADAL DEVELOPMENT AND MAINTENANCE(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- A FEMALE-ATTRACTING ACTIVITY OF STEROIDAL SUBSTANCES IN THE ABDOMINAL GLAND OF THE MALE NEWT, CYNOPS PYRRHOGASTER
- SYNTHESIS OF STEROIDAL SUBSTANCES IN THE ABDOMINAL GLAND OF THE NEWT CYNOPS PYRRHOGASTER
- SEX DIFFERENCE IN THE EXPRESSION OF Ad4BP/SF-1 IN THE DEVELOPING QUAIL BRAIN
- SEX DIFFERENCE IN THE PRODUCTION OF 7α-HYDROXYPREGNENOLONE STIMULATING LOCOMOTOR ACTIVITY IN THE QUAIL BRAIN
- SEX DIFFERENCE IN 7α-HYDROXYPREGNENOLONE SYNTHESIS IN THE BRAIN OF BREEDING NEWTS
- Effects of dry needling at tender points for neck pain (Japanese : katakori) : near-infrared spectroscopy for monitoring muscular oxygenation of the trapezius
- A Prospective Study of De Novo Scoliosis in a Community Based Cohort
- A Longitudinal Study of Congruent Sagittal Spinal Alignment in an Adult Cohort
- EFFECTS OF THYROID HORMONES ON ESTROGEN RECEPTOR EXPRESSION IN THE VENTROMEDIAL HYPOTHALAMUS OF HYPOTHYROIDAL FEMALE MICE(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- P6-31 Effect of Prenatal and Neonatal Exposure to Di(2-ethylhexyl) phthalate on the Metabolism of Testosterone in Rat(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the
- Effect of Prenatal Exposure to PCB 153 (2,2',4,4',5,5'-hexachlorobiphenyl) on the Metabolism of Testosterone in Rats. (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Effects of Prenatal Exposure to PCB153 (2,2',4,4',5,5'-hexachlorobiphenyl) on Schedule-Controlled Operant Behavior in Rats. (NEREVOUS SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- EXPRESSION OF α-MSH IN THE QUAIL BURSA OF FABRICIUS
- HORMONE-LIKE MOLECULES IN THE BURSA OF FABRICIUS
- Impaired Development of Somatotropes, Lactotropes and Thyrotropes in Growth-Retarded (grt) Mice
- DEVELOPMENT OF GROWTH HORMONE(GH), PROLACTIN(PRL) AND THYROID-STIMULATING HORMONE(TSH) CELLS IN THE ANTERIOR PITUITARY GLAND OF THE GROWTH-RETARDED MOUSE
- EXPRESSION OF STEROIDOGENIC ENZYMES IN THE QUAIL BURSA OF FABRICIUS(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Characterization of F_2 Treatment Effects on Si(100) Surface and Si(100)/SiO_3 Interface
- ACTIVITY IN THE NUCLEUS ACCUMBENS CORE NEURONS REFLECTS BEHAVIORAL MODE CHANGE IN THE RAT(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- High-Sensitivity SOI MOS Photodetector with Self-Amplification
- High Sensitivity Photodetector with Self-Amplification Capability
- A case of DNA analysis of ABO blood group variant allele A^2
- A Rare Case of Serous Cystadenoma of the Pancreas Presenting with Left-Sided Portal Hypertension
- The proof of flat-line scalp EEGs of brain dead patients by an automatic EEG analysis system
- PCR-BASED GENOTYPING OF MNSs BLOOD GROUP : SUBTYPING OF M ALLELE TO M^G AND M^T
- Effects of in utero exposure to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) on somatic growth and endocrine status in rat offspring
- EXPRESSION OF STEROIDOGENIC ENZYMES IN THE QUAIL BURSA OF FABRICIUS
- Changes in the sagittal spinal alignment of the elderly without vertebral fractures : a minimum 10-year longitudinal study
- Thyroid-stimulating hormone receptor levels and binding affinity in the thyroid gland of growth-retarded mice
- Examination of seminal stain by HPLC assay of phenolphthalein
- EFFECT OF DAYLENGTH AND SEX DIFFERENCE ON PHEROMONE RECEIPT AND TRANSMISSION IN THE VOMERONASAL OF SIBERIAN HAMSTERS (Phodopus Sungorus) : TRANSMISSION SYSTEM AND SEX DIFFERENCES
- Characterization of Charged Traps near Si-SiO_2 Interface in Photo-Induced Chemical Vapor Deposited SiO_2 Film
- Characterization of Charged Traps near Si-SiO_2 Interface in Photo-CVD SiO_2 Film
- Association between bone loss and promoter polymorphism in the IL-6 gene in elderly Japanese women with hip fracture
- DELAYED DEVELOPMENT OF THE TESTIS IN GROWTH-RETARDED (grt) MICE
- P6-29 Evaluation of toxic effect on sperm of halogenized propans using Tetrazolium Salt, SQA and CASA methods in rats(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the
- Carbonyl Sulfide Concentration in the Arctic Lowermost Stratosphere and Stratosphere-troposphere Transport
- PROSTAGLANDIN E2 PROMOTES EXPRESSION OF BASIC FIBLOBLAST GROWTH FACTOR IN THE HIPPOCAMPUS IN RUTS(Physiology)(Proceeding of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- FIELD ENDOCRINOLOGICAL STUDIES OF BREEDING STRATEGY IN BUSH WARBLERS
- NEURAL RECOGNITION MOLECULE NB-3 OF THE CONTACTIN/F3 SUBGROUP AFFECTS NEUROGENESIS IN THE DENTATE GYRUS(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Age-Associated Changes in the Open Field Behavior of Male Mice of the ICR/SLC Strain
- EFFECTS OF PROSTAGLANDIN E2 ON THE PROLIFERATION OF HIPPOCAMPAL CELLS IN VITRO(Physiology)Proceedings of the Seventy-First Annual Meeting of the Zoological Society of Japan
- EFFECTS OF PROSTAGLANDIN E2 ON PROLIFERATION OF GRANULE CELL PRECURSORS IN THE ADULT RODENT DENTATE GYRUS(Physiology)Proceedings of the Seventy-First Annual Meeting of the Zoological Society of Japan
- Activation of arachidonate cascade by ischeaia(Endocrinology)(Proceedings of the Seventieth Annual Meeting of the Zoological Society of Japan)
- EFFECTS OF LESIONS OF HIPPOCAMPUS AND DENTATE GYRUS ON MAZE LEARNING IN MALE MICE
- MODIFICATIONS OF MAZE LEARNING ABILITY BY ADRENAL STEROIDS AND THEIR RELATION TO NEURONAL ACTIVITIES OF THE HIPPOCAMPUS AND THE DENTATE GYRUS IN MALE MICE
- EFFECTS OF TRIBUTYLTIN CHLORIDE ON THE DEVELOPMENT OF JAPANESE QUAIL EMBRYOS
- EFFECTS OF INFANTILE STIMULATION ON BEHAVIOR AND PHYSIOLOGY IN ADULT MICE
- Relationship between growth retardation and impaired glucose tolerance in hypothyroidal growth-retarded (grt) mice
- PURIFICATION OF CHICK MULLERIAN-INHIBITING SUBSTANCE
- Lack of effects for dietary exposure of bisphenol A during in utero and lactational periods on reproductive development in rat offspring
- Impaired Development of Somatotropes, Lactotropes and Thyrotropes in Growth-Retarded (grt) Mice
- Extension of the Response Time Method and the Areal Heat Diffusion Time Method for One-Dimensional Heat Diffusion after Impulse Heating: Generalization Considering Heat Sources inside of Multilayer and General Boundary Conditions
- Carbonyl Sulfide Concentration in the Arctic Lowermost Stratosphere and Stratosphere-troposphere Transport