Transport of Acebutolol through Rabbit Corneal Epithelium
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概要
- 論文の詳細を見る
The purpose of this study is to characterize transport of acebutolol through the corneal epithelium. Cultured normal rabbit corneal epithelial cells (RCEC) were used to investigate the drug transport. Primary RCEC were seeded on a filter membrane of Transwell-COL? insert coated with fibronectin and were grown in Dulbecco's modified Eagle's medium/nutrient mixture F-12 with various supplements. Measurements of acebutolol permeability through RCEC layer were carried out to assess transcellular permeability coefficient (Ptranscell) in the absence or presence of inhibitors. Paracellular permeability coefficient (Pparacell) was calculated by permeability coefficient of hydrophilic drugs (Pcell). The transcellular permeability of acebutolol from apical side to basal side (A-to-B) showed concentration-dependency. The acebutolol flux in the A-to-B direction was smaller than that of opposite direction. Sodium azide, verapamil, and cyclosporin A enhanced the transcellular permeability of acebutolol in the A-to-B direction. Acebutolol permeability through an excised rabbit cornea was also increased by verapamil. Thus, it was suggested that acebutolol was actively secreted via P-glycoprotein in a corneal epithelium.
- 社団法人日本薬学会の論文
- 2006-04-01
著者
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中島 幹夫
佐賀大学医学部附属病院 手術部
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中島 幹夫
佐賀医科大学手術部
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NAKASHIMA Mikiro
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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SASAKI Hitoshi
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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Nakashima M
Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.
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Nakashima M
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry
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Nakashima Mikiro
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Sasaki H
Dep. Of Hospital Pharmacy Nagasaki Univ. Hospital
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KAWAZU Kouichi
Santen Pharmaceutical Co., Ltd.Nara Research and Development Center.
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ICHIKAWA Nobuhiro
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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NAKAMURA Tadahiro
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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OSHITA Akemi
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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Kawazu Kouichi
Santen Pharmaceutical Co. Ltd. Nara Research And Development Center
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Oshita Akemi
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry
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Ichikawa Nobuhiro
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry
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Nakano M
Department Of Laboratory Medicine Nagasaki University School Of Medicine
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Sasaki Hitoshi
長崎大学 医歯学部病院薬剤部
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Sasaki Hitoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Shiota H
Nagasaki Univ. Nagasaki Jpn
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Sasaki Hajime
Semiconductor Group Mitsubishi Electric Corporation
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Sasaki Hideyuki
R&d Center Toshiba Corp.
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Kobayashi Kazuko
Santen Pharmaceutical Co. Ltd. Nara Research And Development Center
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Sasaki H
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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Sasaki H
Electrotechnical Laboratory
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Sasaki H
Nagasaki Univ. School Of Medicine Nagasaki Jpn
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Sasaki Hitoshi
Department Of Hospital Pharmacy Nagasaki University Hospital
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Nakashima Mikiro
Department of Clinical Pharmacy, Graduate School of Biomedical Sciences, Nagasaki University
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Nakamura Tadahiro
Department of Hospital Pharmacy, Nagasaki University Hospital
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