ACUTE AND SUBACUTE TOXICITY STUDIES ON COLLAGEN WOUND DRESSING (CAS) IN MICE AND RATS
スポンサーリンク
概要
- 論文の詳細を見る
Single administration of collagen wound dressing (CAS) made from bovine derm in the form of finely ground powders was given to mice and rats via i.p., s.c. and p.o. routes and via i.v. route in the form of physiological Saline extracts and it was continuously injected into mice for 28 days via s.c. route to study its acute and subacute toxicity. Examinations were made of on general conditions, body weight, food and water consumption; hematology, serum biohcemistry, organ weight, and gross and microscopic findings. Results showed no marked toxicity except for local irritation which was seen only after parenteral administration. We concluded on the basis of these animal experiments that there should be no problem in regard to safety after somewhat more extensive therapuetic application of CAS as a wound dressing in clinical practice.
- 日本トキシコロジー学会の論文
- 1982-12-25
著者
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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Sasaki Hitoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Kawaoto Haruo
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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YOKOTA Masayuki
Department of Neurosurgery, Hyogo College of Medicine
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Ito Takashi
Department Of Chemistry School Of Science The University Of Tokyo
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Koeda Takemi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Koeda Takemi
Department Of Pathology Showa University School Of Medicine
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Koeda Takemi
Central Research Laboratories Meiji Seika Kaisha Ltd.:(present Address) Kobe Women's College Of
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Yokota Masayuki
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Ishiwatari Nobuyoshi
Laboratory of Toxicology, Central Research Laboratories of Meiji Seika Kaisha Ltd.
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Seki Michihiko
Laboratory of Toxicology, Central Research Laboratories of Meiji Seika Kaisha Ltd.
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Odaki Masuzo
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Seki Michihiko
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Niizato Tetsutaro
Department Of Pharmacology And Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Takeda Ueto
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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TAKEDA Ueto
Department of Pharmacology and Toxicology, Central Research Laboratories of Meiji Seika Kaisha, Ltd.
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ODAKI Masuzo
Department of Pharmacology and Toxicology, Central Research Laboratories of Meiji Seika Kaisha, Ltd.
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KAWAOTO Haruo
Department of Pharmacology and Toxicology, Central Research Laboratories of Meiji Seika Kaisha, Ltd.
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ISHIWATARI Nobuyoshi
Department of Pharmacology and Toxicology, Central Research Laboratories of Meiji Seika Kaisha, Ltd.
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HAYASAKA Hiroyasu
Department of Pharmacology and Toxicology, Central Research Laboratories of Meiji Seika Kaisha, Ltd.
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SEKI Michihiko
Department of Pharmacology and Toxicology, Central Research Laboratories of Meiji Seika Kaisha, Ltd.
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Hayasaka Hiroyasu
Department Of Pharmacology And Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Ishiwatari Nobuyoshi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Sasaki Hitoshi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Yokota Masayuki
Department Of Applied Chemistry Fuculty Of Engineering Nagoya University
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Yokota Masayuki
Dept. Of Pharmacology And Toxicology Central Research Lab. Meiji Seika Kaisha
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Ito Takashi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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Watanabe Hiroshi
Laboratory Of Toxicology Central Research Laboratories Of Meiji Seika Kaisha Ltd.
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Ito Takashi
Department of Chemical Engineering, Graduate School of Engineering, Nagoya University
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ITO Takashi
Department of Advanced Materials Chemistry, Graduate School of Engineering, Yokohama National University
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