Identification and characterization of a novel fermented substance produced by edible Aspergillus oryzae AO-1 that inhibits DPP-IV activity(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

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We identified a novel fermented substance (FKA) produced by the edible Aspergillus oryzae strain AO-1 that inhibited dipeptidyl peptidase IV (DPP-IV) (IC_<50>=3.41mg・mL^<-1>). HPLC analysis of FKA showed specific one metabolite (WYK-1), which inhibited DPP-IV (IC_<50>=6.98μM). WYK-1 was identified as a tetrahydroxyisoquinoline derivative. Interestingly, we examined 60 strains of A.oryzae, AO-1 was the only A.oryzae strain that produces WYK-1. This is the first report that an edible A.oryzae strain produces a DPP-IV inhibitor such as WYK-1. This study also suggests that FKA has applications in the development of novel antihyperglycemic therapeutics or functional foods.