FOLLOW-UP STUDY OF SERUM IMMUNOGLOBULINS IN THYMECTOMIZED CASES OF MYASTHENIA GRAVIS

概要

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1) Blood factors in myasthenia gravisIn this disease, frequency of complication of other autoimmune diseases is high, and blood factors should be discussed with reference to this.(1) Serum γ-globulin seldom gives high value in this disease alone.(2) Regarding the abnormal pattern of serum immunoglobulin, increases and decreases in IgG appeared in equal frequency. For the other im-munoglobulins, IgA is low and IgM is high.(3) Peripheral lymphocyte counts are low in many cases.2) Fluctuations of blood factors in myasthenia gravis following thymectomy(1) Immunoglobulin especially of IgG decreases significantly at an early period after thymectomy, followed by a gradual rise again. Long-term postoperative observation revealed a tendency towards normalization of IgG and IgA.(2) Peripheral lymphocytes significantly decreased at an early postoperative period. Observation for a longer perid revealed a tendency towards normalization.(3) As to the relationship between the therapeutic effects after thymectomy and fluctuations of the blood factors, symptoms improved after opera-tion in cases with postoperative early decrease of IgG and peripheral lymphocytes.(4) In the relationship between the thymic tissue and blood factors, im-munoglobulin especially of IgG gave low values with little postopera-tive changes and having no lymph follicles formation within the thymus.
The Keio Journal of Medicineの論文