EXPERIMENTAL STUDIES ON THE PATHOLOGICAL CHANGES IN THE SEVERAL ORGANS DUE TO IRRITATION OF THE AUTONOMIC NERVOUS SYSTEM

概要

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1. Various lesions were produced in the pancreas, stomach, lungs and adrenals by giving nervous irritation directly to the cervical autonomic nerves, coeliac autonomic ganglia or the splanchnic nerve.2. Production of these lesions were prevented or ameliorated by administration of Chlorpromazine or Cortisone in adequate doses or by hypophysectomy, whereas administration of these agents in larger doses, or of ACTH aggravated these lesions.3. These experimental results were interpreted as indicating that irritation given to the organism induces various lesions in various organs through a direct pathway of peripheral autonomic nerves, as well as through that of peripheral autonomic nerve-diencephalon-pituitary-adrenal axis. In other words, both the autonomic nervous system and pituitary adrenal axis are participating cooperatively with each other, in the pathogenesis of Reilly's phenomena as well as in that of Selye's general adaptation syndrome. Finally, the authors wish to stress that these two unspecific phenomena must be summarized and organized theoretically in a category of "agressology."
The Keio Journal of Medicineの論文