HLA ANTIGENS OF INTRATHYMIC AND PERIPHERAL LYMPHOCYTES IN AUTOIMMUNE DISEASE
スポンサーリンク
概要
- 論文の詳細を見る
The importance of genetic factor became cleared by investigations of HLA antigens in Japanese with autoimmune disease. The HLA antigens of the intrathymic and peripheral lymphocytes in autoimmune disease in Japa nese were studied. The HLA antigens in the peripheral blood were evaluated in 20 cases of myasthenia gravis, 35 cases of ulcerative colitis and 20 cases of Behcet's disease. Of these the HLA antigens in the intrathymic lymphocytes were also studied in 12 cases of myasthenia gravis (4 with thymoma & 8 with thymic hyperplasia) and 3 cases of ulcerative colitis with thymic hyperplasia. Four cases of congenital heart abnormality and 3 cases of fetus were used as control. The NIH Tissue Typing Method was used.The common HLA antigen (HLA-B5) was identified in the peripheral blood of autoimmune disease with thymic abnormality. Significantly high frequencies of HLA-B5 in the peripheral blood in myasthenia gravis, of HLA A9 and HLA-B5 in ulcerative colitis, and HLA-A9 and HLA-B5 in Behcet's disease were observed.The some HLA antigens of intrathymic lymphocytes were negative in 3 cases of myasthenia gravis with thymoma. In thymoma, intrathymic lym phocytes in tumorous section were more negative than those in non-tumorous section in antigenicity of HLA. The negative of the HLA antigens were checked by the absorption inhibition cytotoxicity test. Four out of 8 cases of myasthenia gravis with thymic hyperplasia showed incomplete negative (lesser antigenecity) of HLA antigens in the intrathymic lymphocytes. In ulcera tive colitis with thymic hyperplasia, intrathymic and peripheral lymphocytes showed identical HLA antigens like congenital heart abnormality of children.In myasthenia gravis, close correlation was found between the negative HLA antigens of the intrathymic lymphocytes and positive HLA-B5 in the peripheral blood, as well as the positive antithymus antibody.The results showed the possibility of the primary role of thymus which is genetically destinied in inducing autoimmune process through the HLA anti gens disappearance.
- The Keio Journal of Medicineの論文
著者
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Tsuchiya Masaharu
Department Of Internal Medicine Keio University
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Ono Akira
Department of 2nd Internal Medicine, Faculty of Medicine, Oaka University
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YAMANAKA IKUO
Blood and Tissue Typing Center, Department of Surgery, School of Medicine, Tokai University
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KURITA KEN
Department of Internal Medicine, School of Medicine, Keio University
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TSUJI KIMIYOSHI
Blood and Tissue Typing Center, Department of Surgery, School of Medicine, Tokai University
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