Human thymus retrovirus. Is human thymus retrovirus a pathogenic virus for human autoimmune diseases?:IS HUMAN THYMUS RETROVIRUS A PATHOGENIC VIRUS FOR HUMAN AUTOIMMUNE DISEASES?
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概要
- 論文の詳細を見る
The involvement of retroviruses has been shown in the pathogenesis of autoimmunity in animal models of autoimmune diseases. Changes in the thymus gland are frequently found in a variety of human autoimmune diseases. Abnormal B cell proliferation are observed in such autoimmune thymuses. We cultured thymus cells of autoimmune patients with B cells and observed the appearance of retrovirus particles in the cultured thymus cells. Antibodies to the retrovirus-related antigens were detected in sera of patients with autoimmune diseases. The findings suggest the possibility that activated retroviruses in thymus cells of autoimmune patients may be involved in the pathogenesis of human autoimmune diseases.
- The Keio Journal of Medicineの論文
著者
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Tsuchiya Masaharu
Department Of Internal Medicine Keio University
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Morita Minoru
Department Of Animal Science Faculty Of Agriculture Tohoku University
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Ono Akira
Department of 2nd Internal Medicine, Faculty of Medicine, Oaka University
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KONDO SHUNZO
Department of Developmental Biology, Misubishi-Kasei Institute of Life Science
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MORITA MINORU
Department of Virology, The Kitasato Institute
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OBI KAZUHIRO
Department of Internal Medicine, School of Medicine, Keio University
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