Impact of Menopause on Lipid and Bone Metabolism and Effect of Hormone Replacement Therapy
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概要
- 論文の詳細を見る
Background: Hyperlipidemia and osteoporosis are the medical targets to improve the quality of life of increasing elderly women. Objective: To elucidate the effect of menopause and hormone replacement therapy (HRT) on lipid and bone metabolism. Subjects: With their written informed consent, studied were 89 postmenopausal with 30 premenopausal women, and postmenopausal 35 were assigned into HRT (n=18) or control group (n=17); the former received conjugated equine estrogen (0.625mg/day) and medroxyprogesterone acetate (2.5mg/day), the latter calcium aspartate (800mg/day). Outcome measured: Parameters were measured for lipids; total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), triglycerides (TG), lipoproteins, and apolipoproteins as well as for bone metabolism; parathyroid hormone (PTH), 1, 25(OH)_2D_3, bone type of alkaline phosphatase (b-ALP), intact bone gla protein (I-BGP), tartrate-resistant acid phosphatase (TRAP) in serum. Bone mineral density (BMD) of lumbar spine was measured by dual energy X-ray absorptiometry (DEXA). Two atherogenic indices (AIs) were calculated: Alc equals [TC-HDLC]/HDLC, and AIap equals (apolipoprotein B)/(apolipoprotein Al). Results: TC increased in <sime>10% within 2 years after menopause with increased LDLC (<sime>20%) and decreased HDLC (<sime>10%), and atherogenic indices were both elevated. In HRT, HDLC increased, while TC and LDLC and TG showed no significant change; lumbar BMD increased by 3% after 12 month, while bone formation markers decreased; PTH increased and 1, 25 (OH)_2D_3 decreased. Conclusion: We provided the natural changes of lipid and bone metabolism after menopause and how extent an estrogen replacement can reset these changes.
- 東海大学の論文
著者
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IZUMI Shun-ichiro
Department of Obstetrics and Gynecology, Tokai University, School of Medicine
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Haque S
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medi
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Makino T
Department Of Obstetrics And Gynecology Center For Specialized Clinical Science Tokai University Sch
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Makino Tsunehisa
Departments Of Obstetrics And Gynecology Tokai University
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Makino T
Tokai University
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Sugi Toshitaka
東海大学 医学部産婦人科学
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MATSUBAYASHI Hidehiko
Department of Obstetrics and Gynecology, Tokai University School of Medicine
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HAQUE Shanta
Department of Obstetrics and Gynecology, Specialized Clinical Science, Tokai University School of Me
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MURANO Takayo
Department of Obstetrics and Gynecology, Specialized Clinical Science, Tokai University School of Me
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Suzuki Takahiro
Department Of Chemical Engineering Science Yokohama National University
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Haque Shanta
東海大学 産婦人科
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Haque Shanta
東海大学 医学部産婦人科学
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Murano T
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medi
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Murano Takayo
東海大学
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Murano Takayo
Department Of Obstetrics And Gynecology
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MORI Akira
Department of Clinical Chemistry and Laboratory Medicine Kyushu University
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Haque Shanta
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medi
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Mori Akira
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medi
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KIKA Goh
Department of Obstetrics and Gynecology, Tokai University School of Medicine
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Suzuki T
Department Of Obstetrics And Gynecology Tokai University School Of Medicine
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Ikeda Masae
Department of Obstetrics and Gynecology, Specialized Clinical Science, Tokai University School of Me
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Okuwaki Shinji
Department of Obstetrics and Gynecology, Specialized Clinical Science, Tokai University School of Me
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Okuwaki Shinji
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medi
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GOYA Kenichi
Department of Obstetrics and Gynecology of Specialized Clinical Science, Tokai University School of
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Satoshi Takatori
Osaka Prefectural Institute Of Public Health
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Matsubayashi Hidehiko
Department Of Obstetrics And Gynecology Tokai University School Of Medicine
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Kika Goh
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medi
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Kika Goh
東海大学
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Izumi Shun-ichiro
Department Of Obstetrics And Gynecology Tokai University School Of Medicine
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Izumi Shun-ichiro
Department Of Obstetrics And Gynecology School Of Medicine Keio University
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Goya Ken-ichi
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medi
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Izumi S
Tokai Univ. School Of Medicine
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Makino Tsunehisa
Department Of Obstetrics And Gynecology Center For Specialized Clinical Science Tokai University Sch
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Ikeda Masae
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medi
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Ikeda Masae
Department Of Gynecology Kanagawa Cancer Center Hospital
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Makino Tsunehisa
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medi
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Murano Takayo
Department Of Obstetrics And Gynecology Center For Specialized Clinical Science Tokai University Sch
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Makino Tsunehisa
Department Of Obstetrics And Gynecology Center For Growth And Reproductive Medicine Tokai University
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Izumi Shunichiro
Obstetrics And Gynecology Tokai University School Of Medicine
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Mori Akira
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medi
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Izumi Shun-ichiro
Obstetrics And Gynecology Tokai University School Of Medicine
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Makino Tsunehisa
Department Of Obstetrics And Gynecology
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Suzuki Takahiro
Department Of Anesthesiology Surugadai Nihon University Hospital
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Izumi S
Department Of Obstetrics And Gynecology School Of Medicine Tokai University
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Mori Akira
Department Of Chemistry University Of Western Ontario
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Makino Tsunehisa
Department Of Obstetrics & Gynecology School Of Medicine Tokai University
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Mori Akira
Departmenet Of Animal Husbandry Faculty Of Agriculture Tohoku University
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Mori Akira
Department Of Obstetrics And Gynecology Specialized Clinical Science Tokai University School Of Medicine
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Izumi Shun-ichiro
Department Of Obstetrics And Gynecology
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MAKINO TSUNEHISA
Department of Gynecology and Obstetrics, School of Medicine, Keio University
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Ikeda Masae
Department of Cardiovascular Medicine, National Hospital Organization Fukuyama Medical Center
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