Lactobacillus crispatus KT-11 Enhances Intestinal Immune Functions in C3H/HeN Mice

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概要

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• We investigated the effect of Lactobacillus crispatus KT-11 (KT-11) on intestinal immune systems in C3H/HeN mice. The level of intestinal total immunoglobulin (Ig) A was significantly higher in mice given KT-11 than in mice not given KT-11. Gene expression relating to antibody production and innate immune response increased more than 2-fold in the former compared with the later. Moreover, the number of IL-6+CD11b+ cells was significantly higher in Peyers patch cells cultured with KT-11 than in those cultured without KT-11, although the number of CD4+ cells and the cell ratio of CD4+/CD8+ were remarkably lower in the culture with KT-11. These results indicate that KT-11 enhances intestinal IgA production and innate immune response in C3H/HeN mice.

• 財団法人 学会誌刊行センターの論文

著者

• Otani Hajime

  Interdisciplinary Graduate School Of Sci. And Technol. Shinshu Univ.

• YANAKA Hiroyuki

  KITII Co., Ltd.

• TOBITA Keisuke

  Interdisciplinary Graduate School of Science and Technology, Shinshu University

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