Biphasic Relaxation Caused by Electrical Field Stimulation of the Mesenteric Arteries of Rats
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概要
- 論文の詳細を見る
Electrical field stimulation (EFS) caused biphasic relaxation, first transient and then sustained, of rat mesenteric arteries precontracted by prostaglandin (PG) F2α. The transient relaxation was reduced about 45%, and the sustained relaxation was not observed after endothelium denudation of the arteries. Nω-Nitro-L-arginine (L-NOARG) inhibited the biphasic relaxation induced by EFS. At 1 - 100 μM, L-NOARG inhibited the transient relaxation more than the sustained relaxation. Methylene blue inhibited the biphasic relaxation and at 100 μM, L-NOARG abolished the transient relaxation. These results suggest that the transient relaxation mainly involves nitric oxide (NO), whereas the sustained relaxation involves both NO and some other factor(s).
- 社団法人 日本薬理学会の論文
- 1999-06-01
著者
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Honda Kenji
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Takano Yukio
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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SAITO Ryo
Department of Physics, Graduate School of Science, The University of Tokyo
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Kamiya H
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Science Fukuoka University
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Takano Y
Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn
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Takano Y
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Takano Yukio
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Honda Kenji
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Honda K
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Tanaka Seigo
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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KAMIYA Hiro-o
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Saito Ryo
Department Of Environmental Management Studies Information Mathematics Rakuno Gakuen University
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Takano Yukio
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Kamiya Hiro-o
Department Of Pharmacology Faculty Of Phamaceutical Sciences Fukuoka University
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FUKUMITSU Ai
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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HANDA Kouichi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Fukumitsu Ai
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Kamiya Hiro-o
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Saito Ryo
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Honda Kenji
Department Of Chemistry Toho University
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Kamiya Hiro-o
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Saito Ryo
Department Of Bioscience And Bioinformatics Faculty Of Computer Science And Systems Engineering Kyus
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Saito Ryo
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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KAMIYA Hiro-o
Department of Pharmaceutical Sciences, Fukuoka University
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