Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium-Loaded Rats
スポンサーリンク
概要
- 論文の詳細を見る
We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium–loaded rats and was significantly reduced. This baroreflex sensitivity was reversed by microinjection of the mineralocorticoid receptor (MR) antagonist eplerenone into the NTS. 11β-Hydroxysteroid dehydrogenase type 2 neurons and MR were also identified in the NTS. These data suggest that the aldosterone-sensitive neurons in the NTS may have an important role in baroreflex function.
- 社団法人 日本薬理学会の論文
- 2010-04-20
著者
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Chishaki Akiko
Department of Health Sciences, School of Medicine, Kyushu University
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Honda Kenji
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Takano Yukio
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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SAITO Ryo
Department of Physics, Graduate School of Science, The University of Tokyo
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Nakamura Yusuke
Department of Biochemistry, Cancer Institute
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Takano Y
Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn
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Takano Y
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Chishaki Akiko
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
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Matsuda T
Lab. Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Takano Yukio
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Honda Kenji
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Honda K
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Masuda Tomoharu
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, J
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Hirabara Yasutoshi
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, J
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Tsuruhisa Mai
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, J
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Miyakawa Masayuki
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, J
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Sakamoto Hirotaka
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Japan
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Kawata Mitsuhiro
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Japan
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Saito Ryo
Department Of Environmental Management Studies Information Mathematics Rakuno Gakuen University
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Kawata Mitsuhiro
Department Of Anatomy And Neurobiology Graduate School Of Medical Science Kyoto Prefectural Universi
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Takano Yukio
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Sakamoto Hirotaka
Department Of Anatomy And Neurobiology Kyoto Prefectural University Of Medicine
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Saito Ryo
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Chishaki Akiko
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Honda Kenji
Department Of Chemistry Toho University
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Tsuruhisa Mai
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Miyakawa Masayuki
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Saito Ryo
Department Of Bioscience And Bioinformatics Faculty Of Computer Science And Systems Engineering Kyus
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Nakamura Yusuke
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Nakamura Yusuke
Department Of Biochemistry Cancer Institute
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Hirabara Yasutoshi
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Hirabara Yasutoshi
Department Of Pharmacy University Miyazaki Hospital
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Saito Ryo
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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