Leg Heating Using Far Infra-red Radiation in Patients with Chronic Heart Failure Acutely Improves the Hemodynamics, Vascular Endothelial Function, and Oxidative Stress
スポンサーリンク
概要
- 論文の詳細を見る
Background Systemic thermal therapy (STT) has been associated with beneficial effects in patients with chronic heart failure (CHF). The fact, however, that it requires a dedicated as well as spacious facility and trained personnel makes it difficult to practice in the daily care of patients with CHF. Objective The aim of this study was to determine whether the leg thermal therapy (LTT) has a positive impact similar to that of STT in patients with CHF. Methods and Results Twenty patients with CHF (57±17 years old, left ventricular ejection fraction=30±10%) received LTT (45°C) for 20 minutes. Immediately after the treatment, the core temperature had increased (+0.3±0.3°C) (p<0.01). While the LTT had no significant effects on the heart rate, systolic arterial pressure, and diastolic blood pressure, it increased the cardiac output (mixed venous oxygen saturation; +2±3%) and decrease the pulmonary capillary wedge pressure (-2±2 mmHg). The LTT significantly improved the flow-mediated vasodilatation (FMD) from 4.8±2.6 to 7.1±3.6%, the antioxidative markers, thiol from 4.0±0.7 to 4.5±0.9 μmoL/g, and the marker of oxidative deoxyribonucleic acid (DNA) damage, urine 8-hydroxy-2'deoxyguanosine (8OHdG) from 100 to 82±3%, respectively (p<0.05). No patient had any adverse effects associated with LTT. Conclusion LTT acutely improved FMD, and oxidative stress in patients with CHF. Although the long-term effect of LTT remains to be investigated, its practicality which is comparable to that of STT would make it an attractive therapeutic strategy for patients with CHF.
著者
-
Inoue Shujiro
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
-
Chishaki Akiko
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
-
Ide Tomomi
Department Of Cardiology Kyushu University School Of Medicine
-
Nishizaka Mari
Department Of Cardiology Kyushu University School Of Medicine
-
Miyazono Mami
Department Of Health Sciences Kyushu University Graduate School Of Medical Sciences
-
Takemoto Masao
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
-
Sunagawa Kenji
Department of Advanced Therapeutics for Cardiovascular Diseases, Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
-
Sawatari Hiroyuki
Department of Health Sciences, Kyushu University Graduate School of Medical Sciences
-
Sawatari Hiroyuki
Department of Health Sciences, Kyushu University Graduate School of Medical Sciences, Japan
-
Nishizaka Mari
Department of Cardiovascular Medicine, Kyushu University Hospital, Japan
-
Miyazono Mami
Department of Health Sciences, Kyushu University Graduate School of Medical Sciences, Japan
関連論文
- OJ-212 Nanoparticle-Mediated Intracellular Delivery of Pitavastatin to Endothelial Progenitor Cells Ex Vivo Recovers the Functional Activity for Therapeutic Neovascularization(OJ36,Peripheral Circulation/Vascular Disease (Therapy) 2 (H),Oral Presentation
- FRS-016 Nanoparticle-Mediated Endothelial Cell-Selective Delivery of Pitavastatin Induces Functional Collateral Arteries (Therapeutic Arteriogenesis) in a Rabbit Model of Chronic Hindlimb Ischemia(FRS4,Topics in Peripheral Arterial Disease (H),Featured Re
- Diagnostic Value of the Recovery Time-Course of ST Slope on Exercise ECG in Discriminating False-From True-Positive ST-Segment Depressions
- 7 Anxiety and Poor Social Support are Independently Associated with Adverse Outcomes in Patients with Mild Heart Failure(Is Stress a Risk of Cardiovascular Disease?,Symposium 22 (SY-22) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- 7 Anxiety and Poor Social Support are Independently Associated with Adverse Outcomes in Patients with Mild Heart Failure(Is Stress a Risk of Cardiovascular Disease?,Symposium 22 (SY-22) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- PJ-336 Pitavastatin Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Stenosis, and Prevents Adverse Effects of Silorimus-Eluting Cypher Stent in Porcine Coronary Artery Model(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),T
- FRS-066 When and How should We Use Central BP in Clinical Hypertension? : Report from ABC-J Study(FRS14,New Aspects for Hypertension (H),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-145 Multi-center Cross-sectional Study to Characterize Antihypertensive Treatments in terms of Central Blood Pressure Evaluated by Radial Artery Pulse Waveform(Hypertension, clinical(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting
- Servo-Controlled Hind-Limb Electrical Stimulation for Short-Term Arterial Pressure Control
- PE-467 Donepezil, Acetylcholinesterase Inhibitor, Prevents Progression of Ventricular Remodeling and Dysfunction in Rats after Myocardial Infarction(Heart failure, basic-3 (M) PE78,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of