Stromal Cell-Derived Factor-1α Gene Transfer Induces Therapeutic Angiogenesis by Recruiting Endothelial Progenitor Cells via the VEGF/eNOS Pathway
スポンサーリンク
概要
- 論文の詳細を見る
- 2003-03-01
著者
-
Egashira Kensuke
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
-
江頭 健輔
九州大
-
江頭 健輔
九州大学医学部循環器内科
-
Takeshita Akira
Department of Cardiology, Saiseikai Futsukaichi Hospital
-
Sata Masataka
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
-
Inoue Shujiro
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
-
Zhao Qing-wei
Department Of Cardiovascular Medicine Kyushu University
-
Sata Masataka
Department Of Advanced Clinical Science And Therapeutics Graduate School Of Medicine University Of T
-
Sata Masataka
Department Of Cardiovascular Medicine Tokyo University Graduate School Of Medical Sciences
-
Ishibashi Minako
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medicine
-
Kitamoto Shiro
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medicine
-
Egashira Kensuke
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
-
Zhao Qingwei
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
-
Ohtani Kisho
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
-
Kitamoto Shiro
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
-
Hiasa Ken-ichi
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
-
Hiasa Kenichi
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kyushu University
-
Ohtani Kisyou
Department Of Cardiovascular Medicine Graduate School Of Medicine Sciences Kyushu University
-
Takeshita Akira
Department Of Cardiology Faculty Of Medicine Kyushu University
-
Ohtani Kisho
Department Of Cardiovascular Medicine Graduate School Of Medicine Sciences Kyushu University
-
Ohtani Kisho
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
-
Ishibashi Minako
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kyushu University
-
Tanaka Atsushi
Department Of Cardiovascular Medicine Kyushu University
関連論文
- OJ-212 Nanoparticle-Mediated Intracellular Delivery of Pitavastatin to Endothelial Progenitor Cells Ex Vivo Recovers the Functional Activity for Therapeutic Neovascularization(OJ36,Peripheral Circulation/Vascular Disease (Therapy) 2 (H),Oral Presentation
- FRS-016 Nanoparticle-Mediated Endothelial Cell-Selective Delivery of Pitavastatin Induces Functional Collateral Arteries (Therapeutic Arteriogenesis) in a Rabbit Model of Chronic Hindlimb Ischemia(FRS4,Topics in Peripheral Arterial Disease (H),Featured Re
- スタチン系 (特集 急性冠症候群(ACS)--診断・治療法の進歩) -- (ACSのEBMに基づく薬物療法)
- 末梢血幹細胞(CD34陽性細胞)移植による治療的血管新生療法が有効であった重症虚血性心疾患の1症例(第94回日本循環器学会九州地方会)
- 6. Critical Role of Inflammatory/Arteriogenic Pathway (MCP-1/CCR2 system) in FGF-2-mediated Therapeutic Angiogenesis(第6回群馬県末梢血管病態研究会抄録)
- PJ-336 Pitavastatin Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Stenosis, and Prevents Adverse Effects of Silorimus-Eluting Cypher Stent in Porcine Coronary Artery Model(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),T
- 血管内皮細胞選択的ナノDDSを基盤とするスタチン送達による低侵襲治療的血管新生療法の創製
- REMEDYカテーテルによる冠動脈内遺伝子導入 : ブタおよび人における使用経験
- 冠動脈ステント再狭窄に対してNFkBデコイを冠動脈内に注入した2例(第188回日本循環器学会関東甲信越地方会)
- 炎症性疾患に効果のある遺伝子治療--抗MCP-1遺伝子治療戦略
- 抗MCP-1遺伝子療法によるマウス心移植モデルにおける移植後動脈硬化症の抑制
- Pulmonary Capillary Hemangiomatosis With Severe Pulmonary Hypertension
- 135) バージャー病としては非典型的な病像を呈した末梢動脈疾患の一例(第95回日本循環器学会九州地方会)
- FRS-073 Cardiac 12-lipoxygenase-induced Inflammation is Involved in Heart Failure(FRS15,Novel Molecular Mechanisms of Heart Failure 1 (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-293 Mechanisms Underlying Coronary Vasopsasm at Distal Arterial Segments of Sirolimus-Eluting Stent Implantation in a Porcine Model(OE50,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (English),The 73rd Annual Sc
- OE-059 Cholesterol-lowering Therapy with the Cholesterol Absorption Inhibitor Ezetimibe Inhibits Plaque Destabilization and Rupture in the Brachiocephalic Arteries of ApoE-deficient Mice(OE10,Atherosclerosis, Basic 1 (IHD),Oral Presentation (English),The
- Essential Role of Angiotensin II Type 1a Receptors in the Host Vascular Wall, but Not the Bone Marrow, in the Pathogenesis of Angiotensin II-Induced Atherosclerosis
- PJ-375 Nanoparticle-Mediated Intracellular Delivery of Imatinib, a PDGF-Receptor Tyrosine Kinase Inhibitor, in Porcine Coronary Arteries from Nanoparticle-Eluting Stent Attenuates Neointimal Formation(Restenosis basic/clinical(04)(IHD),Poster Session(Japa
- PJ-170 Blockade of NF-κB by Nano-DDS of NF-κB decoy to the lung ameliorates monocrotaline-induced Pulmonary Arterial Hypertension(Pulmonary circulation(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-222 Nanoparticle-Mediated Delivery of HMG-CoA Reductase Inhibitor (statin)from Nanoparticle-Eluting Stent Attenuates In-Stent Stenosis in Porcine Coronary Arteries in Vivo(Restenosis basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annua
- OE-188 Monocyte-targeting Nanoparticle-based Delivery of Pioglitazone Inhibits Plaque Rupture in the Brachiocephalic Arteries of Apolipoprotein-E Deficient Mice(Atherosclerosis, basic(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting
- FRS-029 Monocyte-Targeting Nanoparticle-Based Delivery of Anti-Monocyte Chemoattractant Protein-1 Gene Inhibits Plaque Rupture of Brachiocephalic Arteries in Apolipoprotein-E Deficient Mice(Novel Mechanisms in Atherosclerosis (IHD),Featured Research Sessi
- 4 Single Intratracheal Administration of Bioabsorbable Nanoparticle Incorporated with Statin Ameliorates Monocrotaline-induced Pulmonary Arterial Hypertension and Survival(Young Investigator's Award for International Students Finalists Lecture (YIA Intern
- PJ-326 Intracellular Delivery of Imatinib (PDGF Receptor Tyrosine Kinase Inhibitor) with Bioabsorbable Polymeric Nanoparticle Technology Effectively Suppresses Vein Graft Neointima Formation(Cardiovascular surgery/CABG-2, The 71st Annual Scientific Meetin
- PE-334 Parallel Increases in LV End-systolic Elastance and Arterial Elastance in Elderly Japanese with Hypertension Make Apparent Systolic Function Normal(Echo/Doppler-12, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-130 Blockade of Vascular Endothelial Cell Growth Factor by Catheter-Based Adenovirus-Mediated Gene Therapy Attenuates In-Stent Neointima Formation in Cynomolgus Monkeys(Atherosclerosis, basic-7, The 71st Annual Scientific Meeting of the Japanese Circul
- PE-037 An Essential Role of Angiotensin II Type 1 Receptor in Arterial Wall, Not in Bone Marrow, in Angiotensin II-Induced Atherosclerosis(Atherosclerosis, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-177 A Novel Nanotechnology-Based Strategy for Therapeutic Neovascularization : Local Delivery of Statin with Biodegradable-Polymeric-Nanoparticle Improves Therapeutic Efficacy of Ischemic Neovascularization(Regeneration (angiogenesis / myocardial regen
- OJ-081 Sustained Intracellular Delivery of Nanoparticles in Porcine Coronary Arteries from a Bioabsorbable Polymeric Nanoparticle-Eluting Stent(Coronary revascularization, PCI-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-646 A Third-generation Long-acting Dihydropyridine Calcium Channel Blocker, Azelnidipine Inhibits Migration/Proliferation of Vascular Smooth Muscle Cells through Suppression of MCP-1 Release(Cardiovascular pharmacology, basic/clinical-5 (H) PJ109,Poste
- OJ-189 Feasibility of Biodegradable Polymeric Nanoparticle Technology for Intracellular Drug Delivery as a Novel Treatment of Vein Graft Disease(Cardiovascular surgery/CABG-1 (IHD) OJ32,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific M
- SF-023-3 ナノ粒子を用いたメシル酸イマチニブ(STI571)細胞内送達は静脈グラフト新生内膜肥厚を抑制する(第108回日本外科学会定期学術集会)
- 47)Pravastatinはコレステロール値とは関係なく冠動脈疾患患者の内皮機能を改善させる(日本循環器学会 第91回九州地方会)
- ナノテクノロジーの循環器疾患への応用 (特集 冠動脈画像診断の進歩--冠動脈CTの現状と将来)
- アンジオテンシン2による炎症と内皮機能障害 (第5土曜特集 レニン・アンジオテンシン系のすべて) -- (RASの病態生理)
- 生体吸収性ナノDDSステントによる革新的血管内ナノ医療の創製
- 1) ナノ粒子を用いたメシル酸イマチニブ(STI571)細胞内送達は静脈グラフト新生内膜肥厚を抑制する(第103回日本循環器学会九州地方会)
- ナノ医工学によるナノDDS技術開発に基づく生体吸収性ナノ粒子コーティングステントの創製(4.新たなるナノテクノロジーとは?,第71回日本循環器学会学術集会)
- 心血管病態・臓器不全の病態におけるMCP-1の役割解明を基盤とするトランスレーショナルリサーチ
- 電着ナノ粒子コーティング技術による新しい生体吸収性ナノ粒子ポリマーを用いた次世代型薬剤, 遺伝子溶出型ステントの開発
- PLGAナノスフェアをプラットフォームとするナノメディシン開発
- ステント内再狭窄の分子機構と生体吸収性ナノ粒子電着による遺伝子溶出ステントがもたらす新たな治療戦略
- ケモカインと動脈硬化 (第5土曜特集 Vascular Biology Update) -- (血管傷害の分子機序)
- 循環器疾患におけるMCP-1の重要性--動脈硬化性疾患を中心に (第5土曜特集 動脈硬化学UPDATE--動脈硬化の成り立ちを理解する) -- (動脈硬化巣やその形成過程に働く生理活性物質と病態)
- 再狭窄に炎症はどのようにかかわるか? (特集 動脈硬化研究の最前線を探る--炎症から再生医学まで)
- 抗炎症による再狭窄予防対策 : 遺伝子溶出ステントによる次世代血管内医療システムの開発(7. Drug-eluting stent時代の幕開けと新技術, 第69回日本循環器学会学術集会)
- 動脈硬化病変の分子機序におけるVEGFの役割に関する研究の新展開 : 血管保護か血管病促進か?
- Angiotensin-Converting Enzyme Activity is Involved in the Mechanism of Increased Endogenous Nitric Oxide Synthase Inhibitor in Patients With Type 2 Diabetes Mellitus
- Angiotensin-Converting Enzyme Activity is Involved in the Mechanism of Increased Endogenous Nitric Oxide Synthase Inhibitor in Type II Diabetes Mellitus
- Renin-Angiotensin System is Involved in the Mechanism of Increased Serum Asymmetric Dimethylarginine in Essential Hypertension
- Stromal Cell-Derived Factor-1α Gene Transfer Induces Therapeutic Angiogenesis by Recruiting Endothelial Progenitor Cells via the VEGF/eNOS Pathway
- 動脈硬化症と血管新生因子シグナル系とのかかわり (特集 血管とリンパ管新生研究の最前線)
- 動脈硬化病変の分子機序におけるVEGFの役割に関する研究の新展開血管保護か血管病促進か?
- Vitamin C Improves Attenuated Angiotensin II-Induced Endothelium-Dependent Vasodilation in Human Forearm Vessels
- FRS-117 An Initial Result of 2-Year Follow Up of 17 Clinical Cases With an NF-κ B Decoy Transfection at the Coronary Stenting(Coronary Revascularization (clinical) 2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Initial Clinical Cases of the Use of a NF-κB Decoy at the Site of Coronary Stenting for the Prevention of Restenosis
- Identification of a novel gene involved in the pathogenesis of cardiac hypertrophy in rats
- レニン-アンジオテンシン系と動脈硬化 (特集 血管病--動脈硬化の成因と治療)
- 炎症性疾患としての冠動脈硬化 (第1土曜特集 虚血性心疾患--分子メカニズムの理解から新しい治療へ) -- (病態生理の理解)
- 循環器系 血管リモデリング--NOと動脈硬化 (第1土曜特集 NOと病態)
- HMG-CoA Reductase Inhibitor Limits Angiotensin II-Induced Progression and Destabilization of Established Atherosclerosis in ApoE-Knockout Mice through Its Cholesterol-Lowering Independent Actions
- Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Limits Progression and Destabilization of Established Atherosclerosis in Apolipoprotein E-Knockout Mice
- Anti-monocyte chemoattractant protein-1 gene therapy inhibits neointimal hyperplasia after balloon angioplasty in rats and monkeys
- Blockade of Vascular Endothelial Growth Factor Signals by sFLT-1 Gene Transer Attenuates Neointimal Hyperplasia after Perivascular Injury in Mice
- Monocyte Chemoattractant Protein-1 is Vital in Angiotensin II-induced Progression and Destabilization of Established Atherosclerosis in Apolipoprotein E-Knockout Mice
- Anti-inflammation Strategy Via Local Gene Transfer with Geneeluting Stents Attenuates in-stent Restenosis in Hypercholesterolemic Rabbits and Monkeys(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 16 (IHD), The 69th Annual Scientific Mee
- PE-318 Vascular Endothelial Growth Factor is an Essential Mediator in the Development of Angiotensin II-induced Arteriosclerosis(Atherosclerosis, Basic 4 (IHD) : PE54)(Poster Session (English))
- OE-123 Blockade or Abrogation of Angiotensin II AT1 Receptor Suppressed Accelerated Diabetic Atherosclerosis in Streptozotosin-Induced Diabetic Apolipoprotein E-Deficient Mice(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
- OE-120 Cholesterol-lowering independent regression and stabilization of atherosclerotic lesions by pravastatin in nonhuman primates(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
- Upregulation of Monocyte Chemoattractant Protein (MCP)-1 Receptor in Circulating Monocytes Contributes to Angiotensin II : Induced Arteriosclerosis/Atherosclerosis
- Soluble FLt-1 Gene Transfer Attenuates Neointimal Hyperplasia after Perivascular Injury in Apoliporotein-E Knockout Mice
- Enhanced Expression of MCP-1 Receptor in Circulating Monocytes in Hypertensive Patients through Angiotensin II Type 1 Receptor
- OE-064 Critical Role of Angiotensin II AT1 Signals in Vascular Senescence in Atherogenesis(Atherosclerosis, basic-1 (H) OE11,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Angiotensin II AT1 Receptor-Mediated Enhanced RAGE Signals are Responsible for the Mechanism of Accerelated Atherosclerosis by Diabetes Mellitus(Atherosclerosis, Basic 10 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 単球走化性促進因子(MCP-1)を標的とした再狭窄予防
- 血管内皮細胞機能に対する作用(1)スタチン系薬 : スタチンの血管内皮細胞機能改善を介する血管保護作用
- OE-183 A New Drug Delivery System Using Fibronectin-VEGF Fusion is More Effective and Harmless than VEGF Alone for the Therapeutic Neovascularization(Growth factor/Cytokine(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japane
- cAMP-Response Element-Binding Protein Mediates Prostaglandin F_2α-Induced Hypertrophy of Vascular Smooth Muscle Cells
- Suppression of Neointimal Formation in a Canine Model of Vein Graft Disease by Adenovirus-Mediated Anti Monocyte Chemoattractant Protein-1 Gene Therapy(Gene Therapy 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Coronary Vascular K+ATP Channels Contribute to the Maintenance of Myocardial Perfusion in Dogs With Pacing-Induced Heart Failure
- Gene Therapy Targeting Monocyte Chemoattractant Protein-1 For Vascular Disease
- Blockade of Vascular Endothelial Growth Factor Attenuates Experimental Restenosis after Intraluminal Injury
- 2 Stent-Based Local Delivery of Nuclear Factor-k B Decoy Attenuates In-Stent Restenosis in Hypercholesterolemic Rabbits(Young Investigator's Award Finalists Lecture (YIA),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- A Third-generation Long-acting Dihydropyridine Calcium Channel Blocker, Azelnidipine Attenuates Stent-associated Neointimal Formation in Hypercholesterolemic Non-human Primates (Restenosis after Angioplasty, Basic/Clinical 6 (IHD), The 69th Annual Scienti
- A Third-generation Long-acting Dihydropyridine Calcium Channel Blocker, Azelnidipine Attenuates Atherosclerosis Through Antioxidant Actions in Hypercholesterolemic Mice and Monkeys(Atherosclerosis, Basic 5 (IHD), The 69th Annual Scientific Meeting of the
- Catheter-based Adenovirus-mediated Local Gene Transfer of Anti-inflammation Factor Attenuates In-stent Neointimal Formation in Non-human Primates(Restenosis after Angioplasty, Basic/Clinical 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circ
- OE-121 Absence of monocyte chemoattractant protein-1 receptor CCR2 on monocytes supresses angiotensin II-induced progression of atherosclerosis in ApoE-deficient mice(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
- FRS-166 Stent-based delivery of nuclear factor-κB(NF-κB) attenuates in-stent restenosis in hypercholesterolemic rabbits(Coronary Heart Disease : Basic Science (IHD) : FRS20)(Featured Research Session (English))
- Anti-Monocyte Chemoattractant Protein-1 Therapy Reduces Experimental In-Stent Restenosis in Hypercholesterolemic Rabbits
- A gene therapy targeting early growth response factor-1 by "decoy" strategy inhibits neointinal hyperplasia in hypercholesterolemic rabbits
- Pioglitazone prevents Coronary Arteriosclerosis through inhibition of inflammation by downregulation of monocyte CCR2 in Rat
- 3 Development of a Novel Bioabsorbable Polymeric Nanoparticle-Eluting Stent by an Actively-Controlled Multilayer Coating Technology(What is New Nano-Technology in the Cardio-vascular Medicine?, The 71st Annual Scientific Meeting of the Japanese Circulatio
- Clinical Importance of Endothelial Function in Arteriosclerosis and Ischemic Heart Disease
- The Role of VEGF System in Restenosis and Arteriosclerosis
- 3 Anti-Monocyte Chemoattractant Protein-1 (MCP-1) Therapy Against Restenosis(Plenary Session 4 (PL4) (IHD) : Restenosis after PCI 2003 : New Therapies for the Next Generation)(Special Program)
- Bone Marrow-derived Monocyte Chemoattractant Protei-1 Receptor CCR2 is Critical in Angiotensin II-induced Vascular Remodeling and Atherosclerotic Process(Recent Advance in the Role of Renin-Angiotensin-Aldosterone System in Atherosclerotic Vascular Diseas
- 4 Nanoparticle-mediated Endothelial Cell-selective Delivery of Pitavastatin Induces Therapeutic Neovascularization(Latest Development of Nanotechnology Revolutionizes Treatments of Cardiovascular Diseases,Topic 3 (TP-3) (H),The 73rd Annual Scientific Meet
- Local Gene Transfer via Gene-Eluting Stents for Prevention of Restenosis : An Anti-inflammation Strategy for Next-Generation Intravascular Therapy(New Technologies in the Drug-Eluting Stent Era, The 69th Annual Scientific Meeting of the Japanese Circulati
- Novel anti-MCP-1 gene therapy against restenosis and atherosclerosis
- Anti-monocyte chemoattractant protein-1 gene therapy protects against experimental autoimmune myocarditis