Servo-Controlled Hind-Limb Electrical Stimulation for Short-Term Arterial Pressure Control

概要

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Background: Autonomic neural intervention is a promising tool for modulating the circulatory system thereby treating some cardiovascular diseases. Methods and Results: In 8 pentobarbital-anesthetized cats, it was examined whether the arterial pressure (AP) could be controlled by acupuncture-like hind-limb electrical stimulation (HES). With a 0.5-ms pulse width, HES monotonically reduced AP as the stimulus current increased from 1 to 5 mA, suggesting that the stimulus current could be a primary control variable. In contrast, the depressor effect of HES showed a nadir approximately 10 Hz in the frequency range between 1 and 100 Hz. Dynamic characteristics of the AP response to HES approximated a second-order low-pass filter with dead time (gain: -10.2 ±1.6 mmHg/mA, natural frequency: 0.040 ±0.004 Hz, damping ratio 1.80 ±0.24, dead time: 1.38 ±0.13 s, mean ± SE). Based on these dynamic characteristics, a servo-controlled HES system was developed. When a target AP value was set at 20 mmHg below the baseline AP, the time required for the AP response to reach 90% of the target level was 38 ±10 s. The steady-state error between the measured and target AP values was 1.3 ±0.1 mmHg. Conclusions: Autonomic neural intervention by acupuncture-like HES might provide an additional modality to quantitatively control the circulatory system.
社団法人　日本循環器学会の論文
2009-04-20