Diagnostic Value of the Recovery Time-Course of ST Slope on Exercise ECG in Discriminating False-From True-Positive ST-Segment Depressions

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Background Using the exercise ECG for diagnosing coronary artery disease (CAD) is hampered by the occurrence of false-positive (FP) ST-segment depression. Because it is known that the recovery ST-T time-course in CAD differs from that in FP subjects, the ST slope may help discriminate FP from true-positive (TP) results. Methods and Results Treadmill digitized ECG from patients with significant ST-segment depressions and normal resting ECG were analyzed in 134 patients with CAD on angiography (>50% narrowing) and reversible perfusion defects (TP group), and 64 subjects with normal perfusion (FP group) on exercise single photon emission computed tomography. The ST slope between the J-point and J_<80> was measured every minute up to 6-min postexercise. The ST slope was significantly higher in FP than in TP at peak exercise, and at postexercise 1-, 2- and 3-min (p<0.01, all). Thereafter, it gradually increased in TP, while monotonically decreasing in FP. Its decrease from 3- to 6-min could correctly diagnose 88% of FP subjects, whereas it was found in only 19% of TP patients (total accuracy 83%). Conclusions The ST slope change from early to late recovery is a simple yet reliable marker for discriminating FP from TP ST-segment responses in subjects with a normal resting ECG. (Circ J 2004; 68: 915-922)
2004-09-20