Modulation by 5-HT_<2A> Receptors of Aggressive Behavior in Isolated Mice
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概要
- 論文の詳細を見る
The present study examines whether isolation-rearing affects sensitivity of 5-hydroxytryptamine (5-HT)2A receptors and the functional interaction between 5-HT1A and 5-HT2A receptors in mice. The 5-HT2A-receptor agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)-induced head twitch response was significantly greater in isolated mice than in grouped mice. DOI increased isolation-induced aggressive behavior, and the 5-HT2A-receptor antagonist ritanserin decreased it. The 5-HT1A-receptor agonist (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole HCl (MKC-242) inhibited the DOI-enhanced aggressive behavior. MKC-242 inhibited DOI-induced head twitch response. These findings suggest that 5-HT2A receptors play a role in aggressive behavior in isolated mice and imply that the antiaggressive effect of MKC-242 may be mediated partly by the inhibition of 5-HT2A-receptor function.
- 社団法人 日本薬理学会の論文
- 2002-05-01
著者
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BABA Akemichi
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers
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Baba A
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Baba Akemichi
Lab. Of Veterinary Pharmacology Graduate School Of Life And Environmental Sci. Osaka Prefecture Univ
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Baba A
Laboratory Of Molecular Neuropharmacology
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Baba Akemichi
昭和大学藤が丘病院 循環器内科
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Baba A
昭和大学藤が丘病院 循環器内科
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Baba A
Osaka Univ. Osaka Jpn
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Baba Akemichi
サントリー生物医学研究所
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Matsuda T
Lab. Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka Univ.
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KOYAMA Yutaka
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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SAKAUE Mzsaki
Laboratory of Molecular Neuropharmacology
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AGO Yukio
Graduate School of Pharmaceutical Sciences, Osaka University
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SOWA Chikako
Graduate School of Pharmaceutical Sciences, Osaka University
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SAKAMOTO Yayoi
Graduate School of Pharmaceutical Sciences, Osaka University
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NISHIHARA Beni
Graduate School of Pharmaceutical Sciences, Osaka University
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KOYAMA Yutaka
Graduate School of Pharmaceutical Sciences, Osaka University
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MATSUDA Toshio
Graduate School of Pharmaceutical Sciences, Osaka University
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SAKAUE Masaki
Laboratory of Molecular Neuropharmacology Graduate School of Pharmaceutical Sciences, Osaka Universi
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Koyama Yutaka
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Matsuda Toshio
Graduate School Of Pharmaceutical Sciences Osaka University
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology
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Ago Yukio
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Sowa Chikako
Graduate School Of Pharmaceutical Sciences Osaka University
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Maeda Sadaaki
Department Of Pharmacotherapeutics Faculty Of Pharmaceutical Sciences Setsunan University
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Sakamoto Yayoi
Graduate School Of Pharmaceutical Sciences Osaka University
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Nishihara Beni
Graduate School Of Pharmaceutical Sciences Osaka University
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Sato Maiko
Lab. Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka Univ. Jpn
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Sakaue Masaki
Laboratory of Molecular Neuropharmacology
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