Edaravone, a Radical Scavenger, Inhibits Mitochondrial Permeability Transition Pore in Rat Brain
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概要
- 論文の詳細を見る
Edaravone, a radical scavenger, prevents ischemia/reperfusion injury in the brain, but the detailed mechanism is not known. This study examines the effect of edaravone on mitochondrial permeability transition pore (PTP) in rat brain. Edaravone at 10 – 100 μM inhibited Ca2+- and H2O2-induced swelling of mitochondria isolated from rat brain. Addition of Ca2+ generated reactive oxygen species (ROS) in isolated mitochondria. Edaravone (10 – 100 μM) inhibited Ca2+-induced generation of ROS. These results suggest that edaravone inhibits opening of mitochondrial PTP in the brain, and they imply that inhibition of mitochondrial PTP may account for the neuroprotective effect of edaravone.
- 社団法人 日本薬理学会の論文
- 2007-04-20
著者
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BABA Akemichi
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers
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Baba A
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Baba Akemichi
Lab. Of Veterinary Pharmacology Graduate School Of Life And Environmental Sci. Osaka Prefecture Univ
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Baba A
Laboratory Of Molecular Neuropharmacology
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Baba Akemichi
昭和大学藤が丘病院 循環器内科
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Baba A
昭和大学藤が丘病院 循環器内科
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Baba A
Osaka Univ. Osaka Jpn
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Baba Akemichi
サントリー生物医学研究所
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Matsuda T
Lab. Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka Univ.
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AGO Yukio
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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MATSUDA Toshio
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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TAKAYASU Yuko
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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NAKAKI Junko
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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KAWASAKI Toshiyuki
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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KODA Ken
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
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Matsuda Toshio
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology
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Koda Ken
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Ago Yukio
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Nakaki Junko
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Takayasu Yuko
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Kawasaki Toshiyuki
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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