Neuropsychotoxicity of Abused Drugs : Effects of Serotonin Receptor Ligands on Methamphetamine- and Cocaine-Induced Behavioral Sensitization in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Repeated administration of psychostimulants elicits a progressive enhancement of locomotor activity known as behavioral sensitization. Central dopamine (DA) neurons play key roles as the neural substrates mediating behavioral sensitization, but the role of the serotonin (5-HT) system in the sensitization is not fully elucidated. We have recently demonstrated that osemozotan, a specific 5-HT1A–receptor agonist, and ritanserin, a 5-HT2–receptor antagonist, inhibited the expression and development of both methamphetamine- and cocaine-induced behavioral sensitization in mice and that these drugs attenuated the maintenance of behavioral sensitization of methamphetamine, but not that of cocaine. We also found that azasetron, a 5-HT3–receptor antagonist, inhibited the expression and development of the sensitization induced by methamphetamine and cocaine, respectively. Neurochemical studies using a microdialysis technique showed that repeated methamphetamine enhanced the methamphetamine-induced increase in 5-HT release in the prefrontal cortex. The sensitization of 5-HT release in methamphetamine-treated mice was attenuated by osemozotan and ritanserin. These findings suggest that the 5-HT system plays an important role in methamphetamine- and cocaine-induced behavioral sensitization in mice and imply that 5-HT1A–receptor agonists and 5-HT2–receptor antagonists may have a potential therapeutic value for the treatment of methamphetamine abuse or psychosis.
- 社団法人 日本薬理学会の論文
- 2008-01-20
著者
-
BABA Akemichi
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka Univers
-
Baba A
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
-
Baba Akemichi
Lab. Of Veterinary Pharmacology Graduate School Of Life And Environmental Sci. Osaka Prefecture Univ
-
Baba A
Laboratory Of Molecular Neuropharmacology
-
Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
-
Baba Akemichi
昭和大学藤が丘病院 循環器内科
-
Baba A
昭和大学藤が丘病院 循環器内科
-
Baba A
Osaka Univ. Osaka Jpn
-
Baba Akemichi
サントリー生物医学研究所
-
Matsuda T
Lab. Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka Univ.
-
AGO Yukio
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
-
NAKAMURA Shigeo
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
-
MATSUDA Toshio
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
-
Matsuda Toshio
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
-
Baba Akemichi
Laboratory Of Molecular Neuropharmacology
-
Ago Yukio
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
-
Nakamura Shigeo
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
-
Baba Akemichi
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
関連論文
- Cardioprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide on Doxorubicin-Induced Cardiomyopathy in Mice
- 15d-Prostaglandin J2 Enhancement of Nerve Growth Factor–Induced Neurite Outgrowth Is Blocked by the Chemoattractant Receptor– Homologous Molecule Expressed on T-Helper Type 2 Cells (CRTH2) Antagonist CAY10471 in PC12 Cells
- Over-Expression of Pancreatic Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Aggravates Cerulein-Induced Acute Pancreatitis in Mice
- Inhibitory Effects of Osemozotan, a Serotonin 1A-Receptor Agonist, on Methamphetamine-Induced c-Fos Expression in Prefrontal Cortical Neurons(Pharmacology)
- An Antihyperkinetic Action by the Serotonin 1A-Receptor Agonist Osemozotan Co-administered With Psychostimulants or the Non-stimulant Atomoxetine in Mice
- Markedly Reduced White Adipose Tissue and Increased Insulin Sensitivity in Adcyap1-Deficient Mice
- PAC1 Receptor-Mediated Relaxation of Longitudianal Muscle of the Mouse Proximal Colon
- Neuropsychotoxicity of Abused Drugs : Effects of Serotonin Receptor Ligands on Methamphetamine- and Cocaine-Induced Behavioral Sensitization in Mice
- Anxiety-Like and Exploratory Behaviors of Isolation-Reared Mice in the Staircase Test
- Edaravone, a Radical Scavenger, Inhibits Mitochondrial Permeability Transition Pore in Rat Brain
- Lack of Enhanced Effect of Antipsychotics Combined With Fluvoxamine on Acetylcholine Release in Rat Prefrontal Cortex
- Functional Proteins Involved in Regulation of Intracellular Ca^ for Drug Development : Pharmacology of SEA0400, a Specific Inhibitor of the Na^+-Ca^ Exchanger
- Protective Effect of T-588 on Toxic Damage by Serum Deprivation and Amyloid-β Protein in Cultured Neurons
- Modulation by 5-HT_ Receptors of Aggressive Behavior in Isolated Mice
- The Nitric Oxide Donor NOC12 Protects Cultured Astrocytes Against Apoptosis via a cGMP-Depentent Mechanism
- Functional Alteration of Brain Dopaminergic System in Isolated Aggressive Mice
- Pituitary Adenylate Cyclase-Activating Polypeptibe (PACAP) Receptor mRNA in the Rat Adrenal Gland: Localization by In Situ Hybridization and Identification of Splice Variants
- Inhibition by Nitric Oxide of the Uptake of [^3H]Serotonin into Rat Brain Synaptosomes
- Interaction of Orally Administered 5-{3-[((2S)-1,4-Benzodioxan-2-ylmethyl)amino]propoxy} - 1,3-benzodioxole (MKC-242)with 5-HT_ Receptors in Rat Brain
- Ouabain : Induced Cell Proliferation in Cultured Rat Astrocytes
- Ca^2+ Depletion Facilitates Taurine Release in Cultured Rat Astrocytes
- Novel Benzodioxan Derivative, 5-{3 - [((2S) - 1,4 - Benzodioxan - 2 - ylmethyl) amino]propoxy} - 1,3 - benzodioxole HCl (MKC - 242), with a Highly Potent and Selective Agonist Activity at Rat Central Serotonin_ Receptors
- INHIBITION OF [^3H] GLUTAMATE RELEASE BY ZN^ IN RAT HIPPOCAMPAL SLICES
- Effect of Diphenylthiocarbazone (Dithizone) on Glutamate Level in Hippocampus Preparation in Vitro and in Vivo
- T-588, a Cognitive Enhancer, Protects Against Sodium Nitroprusside-Induced Toxicity in Cultured Astrocytes
- REGULATION BY GONADAL HORMONES OF 5-HT_ RECEPTOR-MEDIATED ACTIVATION OF HYPOTHALAMUS-PITUITARY-ADRENOCORTICAL AXIS
- AGONIST ACTIVITY OF A NOVEL COMPOUND, BP-554,AT CENTRAL SEROTONIN-1A RECEPTORS
- Effects of Serotonin_ Agonists on Anoxia-Induced Impairment of Protein Synthesis in Rat Brain Slices
- Protective Effect of T-588 on Toxic Damage by Serum Deprivation and Amyloid-β Protein in Cultured Neurons
- Serum-Deprivation Induces Cell Death of Rat Cultured Microglia Accompanied With Expression of Bax Protein
- Role of Na^+/Ca^ Exchanger-Mediated Ca^ Entry in Pressure-Induced Myogenic Constriction in Rat Posterior Cerebral Arteries
- Topics on the Na^+/Ca^ Exchanger : Responses of Na^+/Ca^ Exchanger to Interferon-γ and Nitric Oxide in Cultured Microglia
- Porphyromonas gingivalis Proteinases as Virulence Determinants in Progressin of Periodonatal Diseases
- Design and Synthesis of Sensitive Fluorogenic Substrates Specific for Lys-Gingipain^1
- Pharmacological Aspects of the Acetylcholinesterase Inhibitor Galantamine
- Remarkable Enhancement of Nucleophilicity of Tin Enolates toward Nitro-or Cyanoalkenes by Tetrabutylammonium Halides
- Preparation of α,β-Unsaturated Methyl Ketones from Diketene Using Bis(tributyltin) Oxide
- Reformatsky Type Reaction Promoted by Hexabutyldistannane
- Role of Na+/Ca2+ Exchanger–Mediated Ca2+ Entry in Pressure-Induced Myogenic Constriction in Rat Posterior Cerebral Arteries
- PAC1 Receptor-Mediated Relaxation of Longitudianal Muscle of the Mouse Proximal Colon
- Central Regulation of Urine Production by a Selective μ-Opioid Agonist,[D-Ala^2, N-Me-Phe^4, Gly^5-ol]-Enkephalin, in Rats
- Involvement of Na+/Ca2+ Exchanger in Pentylenetetrazol-Induced Convulsion by Use of Na+/Ca2+ Exchanger Knockout Mice
- Cooperative Action of Arg- and Lys-gingipains in Disruption of Fibronectin-Integrin Interactions in Human Gingival Fibroblasts
- An Antihyperkinetic Action by the Serotonin 1A–Receptor Agonist Osemozotan Co-administered With Psychostimulants or the Non-stimulant Atomoxetine in Mice
- 15d-Prostaglandin J_2 Enhancement of Nerve Growth Factor-Induced Neurite Outgrowth Is Blocked by the Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells (CRTH2) Antagonist CAY10471 in PC12 Cells
- Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium-Loaded Rats
- Suppression of Gingival Inflammation Induced by Porphyromonas gingivalis in Rats by Leupeptic
- MECHANISM OF ACCUMULATION OF TAURINE IN THE HEART OF STARVED RATS
- Topics on the Na+/Ca2+ Exchanger: Responses of Na+/Ca2+ Exchanger to Interferon-γ and Nitric Oxide in Cultured Microglia
- Pharmacological Aspects of the Acetylcholinesterase Inhibitor Galantamine
- The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing-Induced Abnormal Behaviors in Mice
- Preventive Effects of an Enriched Environment on Rodent Psychiatric Disorder Models
- Effect of Prenatal Valproic Acid Exposure on Cortical Morphology in Female Mice
- Placental Extract Improves Hippocampal Neuronal Loss and Fear Memory Impairment Resulting From Chronic Restraint Stress in Ovariectomized Mice
- Placental Extract Improves Hippocampal Neuronal Loss and Fear Memory Impairment Resulting From Chronic Restraint Stress in Ovariectomized Mice
- Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells
- Effect of Overexpression of the Brain-Specific Na^+/Ca^ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells